目前用于治疗指甲牛皮的全身疗法的安全性
Jonathan K Hwang1, Shari R Lipner1
1Weill Cornell Medicine, Department of Dermatology, New York, NY, USA.
Expert opinion on drug safety
|June 17, 2023
概括
针对指甲牛皮的全身治疗,包括生物药物和小分子,提供了更好的结果,但需要仔细监测安全性. 口服免疫调节剂具有有效性,但有明显的禁忌和药物相互作用.
科学领域:
- 皮肤病学 皮肤病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 甲牛皮严重影响生活质量.
- 需要对指甲牛皮的全身治疗安全性进行全面审查.
- 新疗法需要对指甲特定结果进行评估.
研究的目的:
- 对指甲牛皮的全身疗法的安全性概况进行审查.
- 通过详细说明不良事件和考虑因素,为治疗选择提供信息.
- 讨论在特殊人群中使用这些药物.
主要方法:
- 在2023年4月5日进行的PubMed数据库搜索.
- 包括文章讨论系统性指甲牛皮治疗的安全性.
- 对已确定不良事件,禁忌和药物相互作用的文献进行审查.
主要成果:
- 生物疗法 (TNF-α,IL-17,IL-23抑制剂) 和小分子抑制剂 (apremilast,tofacitinib) 提供有针对性的治疗.
- 口服系统性免疫调节剂 (甲基酸盐,环素,乙二烯) 的疗效适度,但安全性问题更频繁.
- 安全性不同,需要仔细考虑禁忌,药物相互作用和监测.
结论:
- 向疗法已经推进了指甲牛皮的治疗方法,但需要持续的安全监测.
- 口服免疫调节剂具有有效性,但存在重大安全考虑,特别是在相互作用方面.
- 进一步的研究对于了解不同患者群体的长期安全性至关重要.
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