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具有不同表面微积分电位差异的合金具有抗菌能力和有利的细胞反应

Chunxia Wang¹, Yueru Hou², Shan Fu³

¹Department of Ophthalmology, Eye Hospital of China Medical University, Key Lens Research Laboratory of Liaoning Province, The Fourth Affiliated Hospital of China Medical University, Shenyang, 110005, China.

Clinical oral investigations

|June 17, 2023

概括

在Ti-Ag合金上的表面微面积电位差 (MAPD) 显示出细菌静止效应. 适度的MAPD增强了线粒体功能并减少了亡,为生物活性合金提供了一个新的战略.

科学领域:

生物材料科学生物材料科学
表面工程是什么?表面工程是什么?
细胞生物学细胞生物学

背景情况:

表面微区域电位差 (MAPD) 提供了独立于金属离子释放的细菌静电性质.
(Ti) 和银 (Ag) 合金正在研究其增强的生物相容性和抗菌活性.
了解MAPD对细胞反应的影响对于生物材料开发至关重要.

研究的目的:

研究不同表面MAPD对Ti-Ag合金抗菌性能的影响.
分析细胞对具有不同MAPD的Ti-Ag合金的反应,包括线粒体功能和亡.
探索改善合金表面生物活性的新策略.

主要方法:

Ti-Ag合金 (T4,T6,S) 是使用真空弧,水和烧结制造的,使用纯cp-Ti作为对照材料.
使用SEM和能量分散谱法分析了微观结构和表面电位分布.
通过盘子计数和活/死染色来评估抗菌性质;通过测量线粒体功能,ATP水平和MC3T3-E1细胞的亡来评估细胞反应.

主要成果:

由于Ti-Ag金属间相的形成,MAPD在Ti-Ag合金之间存在差异,Ti-Ag (S) 呈现最高的MAPD.
具有较高MAPD的合金表现出更强的细菌静止效应.
中度MAPD积极影响了细胞抗氧化剂调节 (GSH/GSSG),减少了细胞内ROS,增强了线粒体膜潜力 (ΔΨm),并降低了亡.

结论:

适度的MAPD在Ti-Ag合金上提供细菌静止作用,同时促进线粒体功能和抑制细胞亡.
这表明MAPD是提高合金表面生物活性的一个有希望的策略.
MAPD为设计改进的合金和解决周植入炎提供了一个潜在的途径.

关键词:

抗菌能力抗菌能力细胞灭亡 (apoptosis) 是一种死亡的过程.在MAPD中,使用的是MAPD.线粒体功能线粒体功能这是一种Ti-Ag合金.

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