肌肉建设补充剂的使用与抵抗训练从业者DNA损伤之间的关联
Patrícia Molz1, Diene da Silva Schlickmann2, Juliana Priebe Steffens3
1Graduate Program in Health Promotion, University of Santa Cruz do Sul, Santa Cruz do sul, Brazil; Laboratory of Experimental Nutrition, University of Santa Cruz do Sul, Santa Cruz do sul, Brazil; Graduate Program in Biosciences, Federal University of Health Sciences of Porto Alegre School of Medicine, Porto Alegre, Brazil.
Nutrition (Burbank, Los Angeles County, Calif.)
|June 17, 2023
概括
这项研究发现,肌肉建设补充剂的使用,即使是那些有强有力的有效性和安全性的证据,也与抵抗训练从业者的临时DNA损伤有关. 然而,没有观察到永久性损伤,这表明这些补充剂可能是安全的消费.
科学领域:
- 运动科学和毒理学
- 营养生物化学 营养生物化学
- 遗传学和分子生物学 遗传学和分子生物学
背景情况:
- 体育补充剂的安全性,特别是关于基因毒性的安全性,尚未得到充分理解.
- 对运动补充剂的DNA损伤进行调查对于运动员的安全至关重要.
- 肌肉建设补充剂被阻力训练从业者广泛使用.
研究的目的:
- 为了检查肌肉建设补充剂消费和阻力训练个体的DNA损伤之间的关联.
- 评估不同类别的肌肉建设补充剂的潜在基因毒性影响.
- 为了解体育补充剂安全概况做出贡献.
主要方法:
- 肌肉建设补充剂根据有效性和安全性的证据 (SESEAS,LMESE,LNESES) 被分类.
- 用彗星测定 (DNA损伤指数和频率) 和口腔微核细胞组测定来评估DNA损伤.
- 307人 (157名补充剂使用者) 参与了调查;数据使用调整的协差分析进行分析.
主要成果:
- 补充剂使用者与非使用者相比,具有显著更高的DNA损伤指数和频率,这正如彗星测定所显示的那样.
- 被归类为支持有效性和明显安全的强有力的证据 (SESEAS) 的补充剂与最高的DNA损伤指数和频率有关.
- 两组之间没有发现微核或核芽的显著差异,这表明DNA损伤是暂时的.
结论:
- 运动补充剂的使用,包括SESEAS类补充剂,与暂时的DNA损伤有关.
- 观察到的DNA损伤不是永久性的,这表明SESEAS补充剂可能是安全的消费.
- 可能需要进一步的研究来阐明补充剂诱导的短暂DNA损伤机制.
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