自然提取物的生物功能化,生物活动的趋势和动力释放
Abraham Osiris Martínez-Olivo1, Víctor Manuel Zamora-Gasga1, Luis Medina-Torres2
1Tecnológico Nacional de México/Instituto Tecnológico de Tepic, Av. Tecnológico 2595, C.P. 63175 Tepic, Nayarit, Mexico.
Advances in colloid and interface science
|June 17, 2023
概括
植物化合物提供健康益处和疾病预防. 提高它们的结构或使用像纳米乳液这样的聚合物矩阵可以提高生物可访问性和生物效应.
科学领域:
- 药理学和植物化学
- 药物输送系统 药物输送系统
- 食品科学与技术 食品科学与技术
背景情况:
- 植物衍生化合物具有重要的生物活性,用于治疗疾病和预防慢性疾病.
- 化学修饰和纳入输送系统可以增强这些化合物的保护性和生物活性性质.
- 了解运动参数对于优化这些植物衍生系统的应用至关重要.
研究的目的:
- 审查从植物中获得生物活性化合物的方法.
- 探索功能化技术,包括双乳液和纳米乳液,以增强化合物输送.
- 评估这些新型捕获系统的毒性和药物动力学概况.
主要方法:
- 从植物来源提取和识别生物活性化合物.
- 植物提取物的功能化使用双乳液和纳米乳液技术.
- 在体外和体内研究评估生物可访问性,生物效应,毒性和药理动力学.
主要成果:
- 植物化合物可以通过结构修改和被困在聚合物矩阵中有效地稳定,并增加其生物可访问性.
- 纳米乳液和双乳液系统显示出保护和增强植物衍生化合物的生物功能.
- 动力学研究对于确定这些输送系统的最佳应用和有效性至关重要.
结论:
- 功能化植物提取物,特别是纳米乳液系统中的植物提取物,为改善健康效益和预防疾病提供了一个有希望的策略.
- 对毒性和药理动力学的进一步研究对于将这些系统成功转化为治疗应用至关重要.
- 本次审查强调了先进的传递系统的潜力,以最大限度地提高天然植物化合物的治疗价值.
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