相关实验视频
Updated: Jul 26, 2025

06:46
Isolation of Exosomes from the Plasma of HIV-1 Positive Individuals
Published on: January 5, 2016
17.4K
耐药结核病患者血外体的特征
Mingrui Wu1, Qianwei Yang2, Caiting Yang2
1Key Laboratory of Cellular Physiology, Ministry of Education, The Department of Physiology, School of Basic Sciences, Shanxi Medical University, Taiyuan, 030001, China.
Tuberculosis (Edinburgh, Scotland)
|June 17, 2023
概括
来自耐药结核病 (DR-TB) 患者的外体显示出改变的阿波利波蛋白水平,可能会影响胆固醇代谢. 这些外体变化可能有助于区分抗药性结核病与非耐药性结核病,并揭示了对疾病发病的新见解.
科学领域:
- 生物化学 生物化学
- 分子生物学分子生物学
- 免疫学 免疫学 免疫学
背景情况:
- 耐药结核病 (DR-TB) 是一个重大的全球卫生挑战.
- 外基因组调解宿主-病原体通信,但它们在DR-TB中的作用尚不清楚.
- 了解外体分子事件对于DR-TB检测和控制至关重要.
研究的目的:
- 为了研究DR-TB患者外体的蛋白质组概况.
- 探索外体蛋白在DR-TB病变发生中的潜在作用.
主要方法:
- 分析了DR-TB和非耐药结核病 (NDR-TB) 患者的血样本.
- 外基因组被分离出来并进行了表征.
- 进行了无标签的定量蛋白质组学和生物信息学分析.
主要成果:
- 与NDR-TB相比,在DR-TB外基因组中,16种蛋白质被上调,10种蛋白质被下调.
- 下调蛋白主要是参与胆固醇代谢的阿波利波蛋白.
- APOA1,APOB和APOC1被确定为外体蛋白-蛋白相互作用网络中的关键蛋白质.
结论:
- 外体蛋白质配置文件可以区分DR-TB和NDR-TB.
- 外体中的阿波利波蛋白 (APOA1,APOB,APOC1) 可能通过调节胆固醇代谢来促进DR-TB的发病.
相关概念视频
Overview of Exosomes
2.8K
Exosomes are stable, lipid bilayer-enclosed vesicles capable of crossing biological barriers. They can carry a wide range of molecules required for intercellular communication. Once exosomes are released from the cell where they originated, they enter a recipient cell through various pathways such as fusion, receptor-mediated endocytosis, macropinocytosis, and phagocytosis.
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
Stahl et al. discovered exosomes in 1983, but the exosomes were initially considered waste products released from the...
2.8K
Pulmonary Tuberculosis V
214
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
214
Pulmonary Tuberculosis I
287
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
287
Pulmonary Tuberculosis III
382
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
The first classification is based on the development of the disease, and it includes the following categories:
382
Pulmonary Tuberculosis IV
175
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
175
Pulmonary Tuberculosis II
281
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
281

