在mRNA BNT162b2和载体Ad26.CoV2.S SARS-CoV-2疫苗接种后,血液静止和炎症标志物的变化
I Ivanko1, I Ćelap2, S Margetić3
1Department of Haematology, Sestre Milosrdnice University Hospital Center, Zagreb, Croatia.
Thrombosis research
|June 17, 2023
概括
在SARS-CoV-2疫苗接种后,人们普遍担心血液凝块. 这项研究发现,在mRNA (BNT162b2) 或载体 (Ad26.CoV2.S) 疫苗接种后,凝血或炎症标志物没有临床显著的破坏.
科学领域:
- 免疫学 免疫学 免疫学
- 血液学 血液学 血液学
- 疫苗学 疫苗学 疫苗学
背景情况:
- 公众对SARS-CoV-2疫苗接种后的血栓栓塞事件的担忧仍然存在.
- 了解不同类型疫苗对血液静止和炎症的影响至关重要.
研究的目的:
- 为了比较BNT162b2 mRNA和Ad26.CoV2.S载体SARS-CoV-2疫苗之间的静血和炎症标志物.
- 通过提供与疫苗相关的凝血和炎症的科学证据来解决公众的担忧.
主要方法:
- 这项研究涉及87名接受BNT162b2和84名接受Ad26.CoV2.S的受试者.
- 测量了包括TAT,F1+2,IL-6,CRP,大内甲蛋白-1,血小板,纤维原,D-二次体和VWF活性在内的关键标志物.
- 针对每个组的疫苗注射,评估了多个时间点.
主要成果:
- 在疫苗接种7天后的Ad26.CoV2.S载体疫苗组中观察到统计学上显著的较高C-反应蛋白 (CRP) 水平.
- 在研究期间,在两种疫苗组中都发现了D-二次体的统计显著增加.
- 这些观察到的凝血标记的变化在临床上是微不足道的.
结论:
- 尽管一些标志物在统计学上有显著的变化,但没有发现临床相关的凝血或炎症过程的破坏.
- 该研究没有提供可信的科学证据,表明BNT162b2 mRNA或Ad26.CoV2.S载体疫苗对凝血或炎症有重大不良影响.
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