补偿性关节机制在前期的帕金森病中保持可理解性
Tabea Thies1, Doris Mücke2, Nuria Geerts3
1University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Neurology, Germany; University of Cologne, Faculty of Arts and Humanities, IfL Phonetics, Germany.
Parkinsonism & related disorders
|June 17, 2023
概括
患有孤立REM睡眠行为障碍的个体表现出改变的语音表达,以补偿保持可理解性. 帕金森病患者表现出进一步的言语运动衰退和减少理解能力.
科学领域:
- 神经学 神经学
- 语音科学 语言科学
- 运动障碍 运动障碍
背景情况:
- 脱发性关节障碍在帕金森病 (PD) 中很常见,并注意到早期的声学语音变化.
- 关节运动,而不仅仅是声学,是理解早期语音变化的关键.
- 在孤立的REM睡眠行为障碍 (iRBD) 中调查动态语音变化,可以了解前兆性PD.
研究的目的:
- 在iRBD的动态水平上调查早期的语音变化.
- 将iRBD和PD扬声器中的关节运动与控制器进行比较.
- 使用电磁关节学来追踪底层的关节运动.
主要方法:
- 从23个控制扬声器,22个iRBD扬声器和23个PD扬声器收集了动态数据.
- 分析了下唇,舌尖和舌头身体运动的幅度,持续时间和平均速度.
- 通过天真的听众评分来评估语音可理解性.
主要成果:
- 与对照组相比,iRBD发言者表现出更大的振幅和更长时间的舌头运动,保持可理解性.
- 与iRBD扬声器相比,PD扬声器表现出较小,较慢的舌尖和下唇运动,听力降低.
- 在prodromal PD中,语言系统的改变是显而易见的,运动障碍与语音减慢和可理解性降低相关.
结论:
- 患有iRBD的个体适应发音模式,尽管有早期运动变化,但保持语音可理解性.
- 语音动力学分析揭示了从iRBD到PD的关节缺陷的明显进展.
相关概念视频
Parkinson's Disease: Treatment
303
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
303
Parkinson's Disease: Overview
611
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
611
Neural Regulation
39.6K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.6K
Prosopagnosia
212
Prosopagnosia, also known as face blindness, is the inability to recognize faces. In severe cases, individuals with prosopagnosia may not recognize close family members, including parents and spouses, by their faces. For instance, someone with prosopagnosia might walk past their child in a crowd, only realizing their mistake upon noticing their child's distinctive backpack or favorite jacket. Prosopagnosia specifically impairs facial recognition, while the recognition of other objects or...
212
Time-Domain Interpretation of PD Control
147
Proportional-Derivative (PD) control is a widely used control method in various engineering systems to enhance stability and performance. In a system with only proportional control, common issues include high maximum overshoot and oscillation, observed in both the error signal and its rate of change. This behavior can be divided into three distinct phases: initial overshoot, subsequent undershoot, and gradual stabilization.
Consider the example of control of motor torque. Initially, a positive...
Consider the example of control of motor torque. Initially, a positive...
147
Larynx
1.7K
The human larynx, often referred to as the voice box, is an intricate organ located in the neck. It serves as a pathway for air to enter the lungs during respiration and is an essential component of voice production.
Anatomy of the Larynx
The larynx consists of various components, including cartilage, muscles, and vocal cords. Its structure includes three large unpaired cartilages—the thyroid, cricoid, and epiglottis—and three smaller paired cartilages—the arytenoids,...
Anatomy of the Larynx
The larynx consists of various components, including cartilage, muscles, and vocal cords. Its structure includes three large unpaired cartilages—the thyroid, cricoid, and epiglottis—and three smaller paired cartilages—the arytenoids,...
1.7K


