同时使用levothyroxine和相互作用的药物在美国的门诊护理访问
Journal of the American Pharmacists Association : JAPhA
|June 17, 2023
概括
利沃甲状腺素 (LT4) 药物相互作用很常见,影响了近四分之一的门诊护理访问. 年龄较大,女性性别和研究年龄较晚增加了同时使用相互作用药物的风险.
科学领域:
- 药理学 药理学是指药理学的学科.
- 药物相互作用 药物相互作用
- 公共卫生 公共卫生
背景情况:
- 利沃甲氧氨酸 (LT4) 是一种广泛处方的药物,治疗指数狭窄.
- 与LT4的药物相互作用 (DDI) 是一个问题,特别是在非处方 (OTC) 药物中.
- 由于在捕获OTC产品使用方面存在挑战,关于LT4DDI的流行情况的数据有限.
研究的目的:
- 调查在美国的门诊护理访问期间与相互作用药物同时使用LT4的频率和模式.
- 确定与这些药物相互作用相关的人口和时间因素.
主要方法:
- 对2006年至2018年全国门诊医疗调查 (NAMCS) 数据的横截面分析.
- 包括已成年患者报告的LT4处方.
- 评估了影响LT4吸收的相互作用药物的使用,例如质子抑制剂.
主要成果:
- 分析了涉及LT4处方的372,942,000次加权访问.
- 与LT4相互作用的药物的同时使用发生在24.4%的访问中.
- 质子抑制剂占相互作用药物的80%. 增加的互动几率与年龄较大 (35-64+),女性性别和以后的研究年份 (2014+) 相关.
结论:
- 在2006年至2018年期间,涉及LT4的门诊护理访问中,近四分之一也涉及药物相互作用.
- 年龄较大,女性性别,以及较晚的学习期与这些相互作用的可能性更高有关.
- 需要进一步的研究,以了解这些同时使用药物的临床影响.
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