改变休息状态神经血管合在患有关节梗塞的患者
Peipei Wang1, Caihong Wang1, Yong Zhang1
1Department of Magnetic Resonance Imaging, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Experimental gerontology
|June 17, 2023
概括
慢性关节梗塞 (PI) 破坏神经血管合 (NVC),影响认知功能. 这项研究发现,受损的NVC,特别是长距离连接,与PI患者的工作记忆缺陷相关.
科学领域:
- 神经成像是一种神经成像.
- 神经学 神经学
- 脑血管疾病 脑血管疾病
背景情况:
- 慢性关节梗塞 (PI) 与运动和认知障碍有关.
- 底层的神经机制,特别是神经血管合 (NVC) 的改变,仍然不清楚.
- 了解NVC变化对于解释PI后的行为缺陷至关重要.
研究的目的:
- 为了研究慢性单侧关节梗塞 (PI) 患者的神经血管合 (NVC) 改变.
- 探索NVC变化与认知障碍,特别是工作记忆之间的关系.
- 阐明PI后行为缺陷的神经基础.
主要方法:
- 使用3D伪连续动脉旋转标记 (3D-pcASL) 和静止状态功能性MRI (rs-fMRI).
- 在49名PI患者和30名对照组中评估脑血流 (CBF) 和功能连接强度 (FCS).
- 通过计算CBF-FCS合和CBF/FCS比率来评估NVC,分析远程和短程连接.
主要成果:
- 在PI患者中,全脑CBF-FCS合被显著破坏.
- 在与认知相关的大脑区域,CBF/FCS比率异常.
- PI更严重地影响了远程NVC,这些变化与工作记忆得分相关.
结论:
- 神经血管合 (NVC) 的破坏是慢性关节梗塞 (PI) 的一个关键特征.
- 损坏的NVC,特别是远程连接,有助于PI患者的认知功能障碍.
- 这些发现凸显了NVC变化作为PI后工作记忆缺陷的潜在神经基础.
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