怀孕期间COVID-19疫苗接种情况与出生体重之间的关系
Priyanka Gaur1, Kristin C Darwin2, Jaden R Kohn2
1Department of Gynecology and Obstetrics, The Johns Hopkins University School of Medicine, Baltimore, MD (Drs Gaur and Uribe).
American journal of obstetrics & gynecology MFM
|June 17, 2023
概括
在怀孕期间完全接种COVID-19疫苗可以显著降低低出生体重的风险. 这一发现强调了全面接种疫苗对孕妇不良分娩后果的保护作用.
科学领域:
- 产科和妇科 产科和妇科
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 孕产妇COVID-19感染与低出生体重 (≤2500g) 有关.
- 之前的研究表明,在接种疫苗和未接种疫苗的孕妇之间,低出生体重风险没有差异.
- 有限的研究存在于不同的疫苗接种状态 (未接种疫苗,不完整,完整) 对低出生体重的影响,通常是由于样本大小小和缺乏共同变量调整.
研究的目的:
- 评估在怀孕期间未接种疫苗,不完整和完整的COVID-19疫苗接种状态与低出生体重之间的关联.
- 为了确定接收的疫苗剂量数量是否会影响对低出生体重的保护作用.
主要方法:
- 使用Vizient临床数据库 (192家美国医院) 进行基于人口的回顾性研究.
- 包括2021年1月至2022年4月期间分娩的孕妇.
- 将参与者分为未接种疫苗,不完全接种疫苗 (1剂量) 或完全接种疫苗 (≥1剂量) 的组.
- 使用多变量逻辑回归和倾向得分匹配以控制混因子.
主要成果:
- 在377,995名参与者中,8.2%的出生体重低.
- 完整的COVID-19疫苗接种与与未接种疫苗的人相比,低出生体重的可能性降低了21% (OR,0.79).
- 在调整了混因素和倾向分数匹配的队列后,完全接种疫苗仍然与低出生体重风险降低相关 (aOR,0.80;aOR,0.78).
结论:
- 在怀孕期间完全接种COVID-19疫苗与分娩低出生体重新生儿的可能性降低有关.
- 这种关联是显著的,即使在调整了许多混因素和大量人口后.
- 这些发现支持完整的COVID-19疫苗接种改善出生结果的好处.
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