燃烧前使用他类药物对代谢和心血管疾病的影响
Tsola A Efejuku1, Grace Obanigba1, Dominique Johnson1
1School of Medicine, University of Texas Medical Branch, Galveston, TX, USA.
American journal of surgery
|June 17, 2023
概括
以前在烧伤患者中使用他类药物会增加高血糖症,心律失常和冠状动脉疾病 (CAD) 的风险. 在男性和燃烧表面面积较大的男性中观察到更高的风险.
科学领域:
- 生物医学研究生物医学研究
- 临床医学 临床医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 类药物广泛用于高脂血症和心血管疾病.
- 它们在患有代谢和心血管结果的烧伤患者中的作用不太清楚.
研究的目的:
- 调查之前使用他类药物与烧伤患者的代谢/心血管结果之间的关联.
- 确定影响这些结果的风险因素.
主要方法:
- 使用了TriNetX电子健康数据库.
- 与之前使用他类药物和没有使用他类药物的烧伤患者进行比较.
- 分析了代谢和心血管疾病的发生率.
主要成果:
- 以前使用他类药物与高血糖 (1.33倍),心律失常 (1.20倍),冠状动脉疾病 (1.70倍) 和败血症 (1.10倍) 的几率增加有关.
- 观察到死亡几率降低 (0.80x).
- 较高的不良结果概率与高百分比的TBSA燃烧,男性性别和脂性他类药物使用有关.
结论:
- 在严重烧伤的患者中,先前使用他类药物与高血糖症,心律失常和CAD的风险增加有关.
- 风险在男性,烧伤表面面积较大的患者和使用脂友性他类药物的患者中进一步扩大.
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