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前列腺活检中的cribriform模式是Ga-PSMA-11 PET/CT上转移性疾病的风险因素吗?
J G Heetman1, R Versteeg2, L Wever2,3
1Department of Urology, Sint Antonius Hospital, Koekoekslaan 1, 3435 CM, Utrecht-Nieuwegein, The Netherlands. j.heetman@antoniusziekenhuis.nl.
World journal of urology
|June 17, 2023
概括
前列腺癌活检中的cribriform模式不能独立地预测PSMA PET/CT扫描上的转移性疾病. 其他因素,如ISUP等级和PSA水平,是转移的重要风险指标.
科学领域:
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
- 病理学 病理学 病理学
背景情况:
- 前列腺癌 (PCa) 的cribriform模式 (CP) 与糟糕的结果有关.
- 作为转移性疾病的独立预测因子,CP的作用需要进一步研究.
研究的目的:
- 确定前列腺活检中的CP是否是PSMA PET/CT检测到的转移性疾病的独立风险因素.
- 为了评估CP和转移性传播在未经治疗的PCa患者之间的关联.
主要方法:
- 对401名未经治疗的PCa患者进行了回顾性分析,分阶段使用68Ga-PSMA-11 PET/CT.
- 进行了回归分析,以评估CP作为转移性疾病的独立风险因素.
- 在基于ISUP等级和风险分层的不同患者子组中进行了二次分析.
主要成果:
- 在63%的患者中存在CP,但不是PSMA PET/CT (p=0.14) 上转移性疾病的独立风险因素.
- 转移性疾病的独立风险因素包括ISUP等级组4和5,更高的PSA水平和临床外扩展 (EPE).
- 在ISUP等级或风险级别分层的子组中,CP没有预测转移性疾病.
结论:
- 前列腺活检中的CP并不是68Ga-PSMA PET/CT上转移性疾病的独立预测因素.
- ISUP等级,PSA水平和EPE是转移性前列腺癌的重要独立风险因素.
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