作为高分辨率标记器的CRISPR阵列,用于跟踪流感感染期间的微生物传播
Lingdi Zhang1, Jahan Rahman1, Matthew Chung2
1Department of Biology, Center for Genomics and Systems Biology, New York University, New York, NY, 10003, USA.
Microbiome
|June 17, 2023
概括
流感会破坏呼吸道微生物,增加家庭内的细菌共享. 克里斯普尔间隔器有效地追踪呼吸道细菌的传播,揭示了个体之间的共享共生和病原生物.
科学领域:
- 微生物组研究的研究.
- 传染病流行病学 传染病流行病学
- 转基因组学是指转基因组学.
背景情况:
- 像流感这样的呼吸道感染可以改变呼吸道微生物群,可能会影响细菌病原体的传播.
- 家庭微生物组研究表明,家庭内部的相似性比家庭之间的相似性更大.
- 这项研究调查了流感感染是否会增加家庭内的呼吸道细菌共享.
相关概念视频
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CRISPR stands for Clustered Regularly Interspaced Short Palindromic Repeats is a adaptive immune system found in bacteria and archaea that protects against viral infections. This system enables prokaryotic cells to identify, remember, and neutralize foreign genetic elements, primarily bacteriophages, by storing fragments of the invader’s DNA as a genetic memory.The CRISPR immune response begins during an initial infection. Cas (CRISPR-associated) proteins play a central role in this...
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Bacteria and archaea are susceptible to viral infections just like eukaryotes; therefore, they have developed a unique adaptive immune system to protect themselves. Clustered regularly interspaced short palindromic repeats and CRISPR-associated proteins (CRISPR-Cas) are present in more than 45% of known bacteria and 90% of known archaea.
The CRISPR-Cas system stores a copy of foreign DNA in the host genome and uses it to identify the foreign DNA upon reinfection. CRISPR-Cas has three different...
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