癌症幸存者的心房动 - 一个系统的审查和元分析
Yueyang Bao1, John Lee2, Udit Thakur3
1School of Medicine, University of Tasmania, Hobart, TAS, Australia.
Cardio-oncology (London, England)
|June 17, 2023
概括
与普通人群相比,癌症幸存者没有显著增加心房动 (AF) 的风险. 这项研究分析了癌症治疗后12个月内个体的AF检测率.
科学领域:
- 心脏病学 心脏病学
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 心房动 (AF) 是癌症患者常见的心脏并发症.
- 目前的指导方针建议65岁及以上的个人进行AF查,但缺乏针对癌症幸存者的具体建议.
- 癌症幸存者与普通人群中AF的比较风险仍然不清楚.
研究的目的:
- 为了比较癌症幸存者的AF检测率与普通人群的AF检测率.
- 评估癌症治疗后个体的长期AF风险.
主要方法:
- 在PubMed,Embase和Web of Science进行了系统的文献搜索,寻找有关AF和癌症的研究.
- 包括的研究集中在18岁以上的成年人身上,超过12个月的癌症治疗后.
- 使用随机效应模型计算了整体AF检测率,用于异质性分析的元回归.
主要成果:
- 分析了16项研究,显示AF联合检测率为4.7% (95%CI为4.0-5.4%).
- 综合年化AF率为0.7% (95% CI为0.1-0.98%),观察到显著的异质性 (I2 = 99.8%,p < 0.001).
- 在乳腺癌队列 (6项研究) 中,年化AF率为0.9% (95% CI 0.1-2.3%),同样具有显著的异质性.
结论:
- 与一般人群相比,癌症幸存者在治疗后12个月以上的AF率并没有显著增加.
- 由于实质性的研究异质性,应谨慎解释结果.
- 可能需要进一步的研究来澄清特定癌症幸存者群体的AF风险.
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