基于大麻sativa的油可以预防由引起的神经毒性
Carla Alves1,2, Wagner Antonio Tamagno3,4, Ana Paula Vanin5
1Biochemistry and Molecular Biology Laboratory Rosilene Rodrigues Kaizer, Instituto Federal de Educação, Ciência e Tecnologia do Rio Grande do Sul, Campus Sertão, Sertão, RS, Brazil.
Scientific reports
|June 17, 2023
概括
Cannabidiol (CBD) 和delta-9-tetrahydrocannabinol (THC) 油显示出对斑马鱼中引起的神经毒性的保护作用. 这些化合物可能有助于预防暴露在中的神经和抗氧化剂损伤.
科学领域:
- 神经科学是一个神经科学.
- 毒理学 毒理学 毒理学
- 药理学 药理学是指药理学的学科.
背景情况:
- 类药物,包括来自Cannabis sativa的delta-9-tetrahydrocannabinol (THC) 和cannabidiol (CBD),在治疗神经疾病和减少神经衰竭方面具有潜力.
- (Al) 是一种已知的神经毒素,可以在高度下引起中毒和神经毒性,其精确的生理作用仍在研究中.
研究的目的:
- 评估CBD和THC丰富油对诱导的神经毒性的潜在保护作用.
- 在斑马鱼模型中评估这些油对行为和生物化学标记物的影响.
主要方法:
- 斑马鱼暴露在 (Al) 中,并用两种不同剂量的富含CBD和THC的油来治疗.
- 用新型坦克测试 (NTT) 和社会偏好测试 (SPT) 评估行为生物标志物.
- 测量了生物化学标记物,包括乙胆酶 (AChE) 活性和抗氧化酶水平 (catalase,超氧化物失变酶,谷氨-S转移酶).
主要成果:
- 基于CBD和THC的油增加了乙胆酶 (AChE) 活性,支持胆系统功能,对抗Al毒性.
- 观察到的行为生物标志物的变化表明,油对Al诱导的神经毒性的保护作用.
- 生物化学分析显示,抗氧化酶活性增强,表明氧化应激减少.
结论:
- 富含CBD和THC的油在斑马鱼模型中显示出对引起的神经毒性的保护作用.
- 这些发现表明,CBD和THC可能有助于预防与中毒相关的神经和抗氧化剂损伤.
- 需要进一步研究这些类素在神经退行性疾病和毒素引起的损伤方面的治疗潜力.
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