马在公路运输后的炎症状况和急性应激反应
Francesca Arfuso1, Maria Rizzo1, Claudia Giannetto2
1Department of Veterinary Sciences, University of Messina, 98168, Messina, Italy.
Scientific reports
|June 17, 2023
概括
道路运输显著改变马的免疫状态,增加白细胞数量和炎症标志物. 这项研究将下丘脑-垂体-上腺轴的激活与马中的这些运输诱导的炎症反应联系起来.
科学领域:
- 马类生理学 马类生理学
- 兽医免疫学 兽医免疫学
- 动物对压力反应的反应
背景情况:
- 道路运输是马匹常见的压力因素.
- 了解运输的生理影响对于动物福利至关重要.
- 脑下垂体上腺 (HPA) 轴和炎症反应是压力的关键指标.
研究的目的:
- 为了评估马的道路运输后血液参数的变化.
- 评估HPA轴与运输后炎症反应之间的关系.
- 研究运输对马体免疫状况的影响.
主要方法:
- 在218公里公路运输后,从10匹马休息和多个时间点收集的血液样本.
- 分析白细胞计数 (WBC),血清皮质醇,C反应蛋白 (CRP),总蛋白质,白蛋白和全球蛋白分数 (α1-, α-2, β1-, β2-, γ-).
- 统计分析包括皮尔森的相关性来评估变量之间的关系.
主要成果:
- 与休息相比,运输后WBC,皮质醇,CRP,α1-,α-2和β2-血球蛋白显著增加 (p < 0.001).
- 运输后观察到白蛋白和白蛋白/血球蛋白 (A/G) 比率显著下降 (p < 0.001).
- 皮质醇和白细胞/炎症标志物之间的负相关性;白细胞和CRP/血球蛋白之间的正相关性.
结论:
- 道路运输会在马中诱导一种类似炎症的状态.
- 在应对运输压力时,HPA轴激活和急性相反应是相互关联的.
- 运输对马的免疫状况产生重大影响,突出了福利问题.
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