功能连接 变化在衰老的认知灵活性:全球和本地交换机成本的不同模式
Ting Li1, Haishuo Xia1, Huai Li1
1Key Laboratory of Cognition and Personality of Ministry of Education, Faculty of Psychology, Southwest University, Chongqing 400715, China.
概括
老龄化会损害认知灵活性,影响全球但不影响本地任务切换成本. 大脑连接的变化不同于每个成本,揭示了老年人的独特的神经模式.
科学领域:
- 神经科学是一个神经科学.
- 认知心理学 认知心理学
- 衰老研究研究 衰老研究
背景情况:
- 认知灵活性对于适应不断变化的环境至关重要,随着年龄的增长而下降.
- 这种下降通常通过任务切换成本来衡量,特别是全球和本地切换成本.
- 功能性大脑连接的年龄相关变化与认知灵活性有关,但全球与本地成本的机制尚不清楚.
研究的目的:
- 调查与年龄相关的功能连接的差异,以了解全球和本地切换成本的基础.
- 确定与全球和本地认知灵活性相关的独特的神经机制.
主要方法:
- 利用功能磁共振成像 (fMRI) 数据的支持矢量机器分析.
- 在指令式任务交换任务中,比较了老年人 (n=32) 和年轻人 (n=33) 之间的功能连接模式.
主要成果:
- 老年人表现出全球切换成本的行为下降,但不是当地切换成本.
- 对于全球和本地切换成本,在功能连接中发现了明显的与年龄相关的变化.
- 多变量连接变化是特定于局部切换成本的,而特定的与年龄相关的连接 (例如,左背前运动皮质-左前皮质) 被确定为全球切换成本.
结论:
- 这项研究提供了不同的神经模式的新证据,这些神经模式是衰老中全球和本地切换成本的基础.
- 阐明了与年龄相关的认知灵活性变化有助于不同的连接机制.
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