尿酸与心血管疾病发病率有关
Carolina Donat-Vargas1,2,3, Pilar Guallar-Castillon3, Jenny Nyström1
1Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Journal of internal medicine
|June 18, 2023
概括
尿中酸盐水平升高,通常来自加工食品,与心血管疾病 (CVD) 有关. 这项研究表明,高酸盐摄入量可能会超出基本营养需求而带来心血管风险.
科学领域:
- 生物化学 生物化学
- 流行病学 流行病学
- 心血管研究研究心血管研究
背景情况:
- 尿液中酸盐 (P) 含量升高可能表明从食品添加剂中大量摄入无机P盐.
- 血P升高与血管功能障碍和化有关.
研究的目的:
- 研究尿液和血中酸盐水平,食酸盐摄入量和心血管疾病 (CVD) 发生率之间的关系.
主要方法:
- 一项基于人口的队列研究,包括来自瑞典乳腺癌队列-临床的1625名女性.
- 测量了尿液和血中的酸盐含量,并使用食物频率问卷估计了饮食摄入量.
- 通过注册链接确定了事件心血管疾病病例,并使用Cox比例危险回归分析.
主要成果:
- 平均随访时间为9.4年后,记录了164例心血管疾病病例.
- 尿酸与独立于其他因素的复合心血管疾病和心肌梗塞 (MI) 风险增加有关.
- 血酸与心血管疾病风险呈现出类似的趋势,尽管在统计学上并不显著.
结论:
- 尿路酸盐水平较高,可能反映了加工食品的高消费,与心血管疾病有关.
- 需要进一步的研究来评估超出营养要求的过度酸盐摄入的心血管毒性.
相关概念视频
Urinary Tract Calculi IV: Nutrition Therapy and Prevention
11
Management of renal calculi focuses on effective strategies like tailored nutrition and hydration therapy. Adjusting diet and fluid intake reduces stone formation and recurrence, making these interventions simple yet powerful in kidney stone prevention and management.Understanding Kidney StonesKidney stones form when calcium, oxalate, uric acid, and cystine concentrate and crystallize in urine. Factors contributing to their formation include genetic predisposition, certain medical conditions,...
11
Urinary Tract Calculi I: Introduction
19
Renal calculi, or kidney stones, are solid deposits of minerals and salts formed inside the kidneys. In medical terminology, "calculus" refers to the stone itself, while "lithiasis" describes the process of stone formation. Depending on their location within the urinary system, these stones may be classified as either urolithiasis, when situated within the urinary tract, or nephrolithiasis, when located within the kidneys. Each term signifies the specific impact of the stone.Predisposition...
19
Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations
16
Renal calculi, commonly termed kidney stones, are crystalline solid masses that form in the kidneys but can occur at any point within the urinary system, encompassing the kidneys, ureters, bladder, and urethra.The pathophysiology of renal stones involves several key factors: supersaturation of the urine with stone-forming constituents, changes in urine pH, a decrease in urine volume, and the presence of substances that promote or inhibit stone formation.Supersaturation of Urine: This is the...
16
Chronic Kidney Disease II: Clinical Manifestations
42
Chronic Kidney Disease (CKD) progressively impairs multiple body systems due to the accumulation of uremic toxins, which disrupt cellular functions across various organs.Neurologic symptomsNeurologic symptoms often arise early in CKD, as uremic toxin buildup drives changes in cognitive and motor functions. Patients frequently experience fatigue, headache, confusion, difficulty concentrating, and, in severe cases, seizures. Peripheral neuropathy commonly manifests as burning sensations in the...
42
Urinary Tract Calculi III: Medical Management
9
The diagnosis of renal calculi involves several imaging techniques, including non-contrast CT scans and ultrasound. These methods help visualize kidney stones, assess their size and location, and detect possible obstructions. Additionally, Measuring urine pH is useful for diagnosing specific stone types, such as struvite (alkaline pH) and uric acid stones (acidic pH). Cystine stones are primarily linked to cystinuria, a genetic condition. A urinalysis helps detect blood in the urine (hematuria)...
9
Nursing Assessment of the Genitourinary System I: Health History
33
The genitourinary system is critical to maintaining fluid balance, waste elimination, and reproductive function. Nurses play a vital role in assessing this system, beginning with a thorough health history. This process involves gathering patient information, identifying risk factors, and recognizing symptoms of genitourinary disorders. Early detection is vital for timely interventions and management.1. Gathering Patient InformationA complete health history includes the patient’s personal,...
33


