产前暴露于多环芳和早期儿童的认知
Bob Sun1, Erin R Wallace2, Yu Ni2
1Division of Pulmonary Medicine, Boston Children's Hospital, Boston, MA, USA.
Environment international
|June 18, 2023
概括
在一项大型研究中,对多环芳 (PAHs) 的产前暴露对儿童智商产生了有限的不良影响. 然而,怀孕早期的PAH暴露可能会影响认知发育,这表明怀孕期间的关键窗口.
科学领域:
- 环境健康 环境健康
- 发展性毒理学 发展性毒理学
- 流行病学 流行病学
背景情况:
- 孕期暴露于多环芳 (PAHs) 的证据对儿童的不良认知结果有混合的证据.
- 怀孕期间的临界暴露窗口在很大程度上是未知的.
研究的目的:
- 调查产前多环芳 (PAH) 暴露与儿童智商 (IQ) 之间的关联.
- 探索儿童性别和母亲肥胖的潜在效果修饰.
- 为了确定怀孕期间暴露的关键窗口.
主要方法:
- 在ECHO-PATHWAYS联盟中利用了两个合并的潜在怀孕队列 (CANDLE和TIDES,N=1,223) 的数据.
- 在怀孕中期 (两个队列) 和怀孕早期/晚期 (TIDES) 测量了七种尿液单氧化PAH代谢物.
- 用多变量线性回归和混合物的加权定量和和回归来评估4-6岁的儿童智商.
主要成果:
- 聚合分析显示,总体PAH代谢产物或混合物与儿童智商之间没有显著的关联.
- 对于2-hydroxynaphthalene,观察到性别的显著相互作用,男性有负面关联,女性有积极关联.
- 在TIDES队列中,怀孕早期的2-基南暴露与IQ相反相关.
结论:
- 有限的证据表明,怀孕早期的多环芳 (PAH) 暴露可能与儿童智商较低有关.
- 在整个怀孕期间进行多次暴露测量可以提高检测关联和识别敏感窗口的能力.
- 建议通过重复的PAH评估进行进一步的研究,以确认发现并了解关键暴露时间.
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