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Updated: Jul 26, 2025

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A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
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目前的治疗模式和在单一机构中晚期黑色素瘤的结果
Michelle A Rose1, John Miura2, Cimarron Sharon3
1Perelman School of Medicine, University of Pennsylvania, Philadelphia Pennsylvania.
The Journal of surgical research
|June 18, 2023
概括
从2009年到2019年,晚期黑色素瘤的免疫疗法使用量显著增加. 尽管有这种趋势,但免疫治疗的时间并没有影响该患者队列的生存结果.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 临床研究 临床研究
背景情况:
- 先进的黑色素瘤治疗已经发展成为新的全身疗法.
- 免疫疗法在治疗晚期黑色素瘤方面取得了重大进展.
研究的目的:
- 分析在晚期黑色素瘤中免疫疗法的利用模式.
- 评估免疫疗法使用与生存结果之间的关联.
主要方法:
- 对244名患有第3期和第4期黑色素瘤的患者进行了回顾性队列研究 (2009-2019).
- 卡普兰-梅尔分析和考克斯回归评估了整体生存期 (OS) 和无进展生存期 (PFS).
主要成果:
- 在研究期间,免疫疗法使用量从2%上升到23%.
- 淋巴血管侵入和第四阶段疾病与较差的生存率有关.
- 女性性别与改善的生存率有关;免疫治疗的时间没有显著影响结果.
结论:
- 免疫疗法越来越多地用于晚期黑色素瘤治疗.
- 免疫治疗的时间与这一队列的生存结果没有显著关联.
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