酸乳糖 改变凝血动力学 活体外
Jacob B Schriner1, Atharwa Mankame2, Scott D Olson3
1Department of Surgery, Center for Translational Injury Research, McGovern Medical School at The University of Texas Health Science Center at Houston, Houston, Texas.
The Journal of surgical research
|June 18, 2023
概括
酸-糖 (CPD) 不会影响血小板功能或凝块强度. 然而,与蓝顶酸盐 (BTC) 管相比,CPD可以通过减少血栓生成来改变血栓动态.
科学领域:
- 血液学 血液学 血液学
- 输血医学 输血医学
- 生物化学 生物化学
背景情况:
- 在美国,酸-酸盐-乳糖 (CPD) 是血液制品的标准抗凝剂.
- 关于CPD对输血后血液功能的影响的研究有限.
研究的目的:
- 为了比较CPD与标准蓝顶酸盐 (BTC) 管对血小板激活和凝块形成的影响.
- 研究CPD对关键静血参数的影响.
主要方法:
- 从健康的捐赠者收集血液样本,并用CPD或BTC进行抗凝血.
- 使用流式细胞计 (FC) 评估了血小板激活.
- 全球血栓形成的评估是使用血栓elastography (TEG) 和血栓收缩试验 (zFlex).
主要成果:
- 血小板激活显示CPD和BTC之间的差异很小,在刺激时CPD中的CD62p表达更高 (P=0.007).
- 在CPD样本中,TEG显示反应时间 (R-时间) 和动力学时间 (K-时间) 显著较长 (P<0.001).
- 在CPD和BTC组中,最大凝块幅度 (MA) 和凝块收缩强度相似 (分别P=0.33和P=0.39).
结论:
- 长期血小板疾病似乎不会损害血小板功能或最终凝块强度.
- 慢性血栓发作可能会通过潜在的减弱血栓生成来影响血栓动态,正如改变的TEG参数所示.
- 需要进一步的研究,以充分阐明这些发现的临床影响.
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