长期血压变化与老年人皮层厚度之间的关系
D S Gutteridge1, A Segal2, J J McNeil3
1Cognitive Ageing and Impairment Neuroscience Laboratory (CAIN), University of South Australia, Adelaide, South Australia, Australia.
Neurobiology of aging
|June 18, 2023
概括
高血压变化 (BPV) 与老年人脑皮层变薄有关. 这种扩张性BPV可能预测皮质更快地变薄,影响认知健康.
科学领域:
- 神经学 神经学
- 老年学是一门学科.
- 心血管研究研究心血管研究
背景情况:
- 高血压变性 (BPV) 是认知能力下降和痴呆症的新兴风险因素.
- 长期BPV与大脑结构变化,特别是皮质厚度之间的确切关系在老年人群中仍然不完全理解.
研究的目的:
- 调查长期血压变化 (BPV) 与社区居住的老年人皮层厚度之间的关联.
- 为了确定透气BPV是否能预测皮质稀释随时间的推移.
主要方法:
- 利用地形方法分析了478名老年人 (70-88岁) 的皮层厚度.
- 测量了长期的BPV,使用了三年来每年访问的平均真实变化.
- 在统计分析中控制平均血压.
主要成果:
- 较高的扩张性BPV显着与时,头顶和前脑区域皮质厚度的减少有关.
- 在为期三年的研究期间,增加的透析BPV与皮质稀薄的速度更快相关.
- 即使考虑到平均血压,这些关联仍然很重要.
结论:
- 扩张性血压变化是老年人皮层厚度的重要独立预测因素.
- 扩张性BPV还可以预测皮质稀薄的轨迹,这表明它对大脑结构有直接影响.
- 这些发现突出了一个潜在的生物机制,将BPV与衰老中的认知障碍联系起来.
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