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一项针对中国人口的尿的全国性大规模研究

Senyuan Huang¹, Dedong Wang², Zenghua Qi¹

¹Guangdong-Hong Kong-Macao Joint Laboratory for Contaminants Exposure and Health, Guangdong Key Laboratory of Environmental Catalysis and Health Risk Control, Institute of Environmental Health and Pollution Control, Guangdong University of Technology, Guangzhou, 510006, PR China; Guangzhou Key Laboratory of Environmental Catalysis and Pollution Control, Key Laboratory of City Cluster Environmental Safety and Green Development, School of Environmental Science and Engineering, Guangdong University of Technology, Guangzhou, 510006, PR China.

The Science of the total environment

|June 18, 2023

概括

这项研究测量了中国的双A (BPA) 和TBBPA暴露,在东部地区发现更高的水平,以及与教育和年龄的联系. 虽然风险很低,但该研究为公共卫生战略提供了信息.

科学领域:

环境健康环境健康
毒理学毒理学毒理学
公共卫生公共卫生

背景情况:

双A (BPA) 和四双A (TBBPA) 是广泛使用的化学品,在中国未知大规模暴露和健康风险数据.
之前的调查缺乏对全国范围内这些化合物的暴露水平,影响因素和与这些化合物相关的健康风险的系统分析.

研究的目的:

为了确定中国人口中BPA,其类似物,TBBPA及其替代品的内部暴露水平.
确定影响暴露的因素,如地区,教育,年龄和饮食习惯.
评估与BPA暴露相关的潜在非致癌性健康风险.

主要方法:

分析了来自中国26个省会的1157个早晨尿样.
测量BPA,七种双相似物,TBBPA,四双A和4,4'-硫二 ((2,6-二二).
使用参考剂量 (RfD) 和蒙特卡洛模拟的健康风险评估.

主要成果:

双S和BPA是被检测到的主要环境.
在中国东部观察到更高的双暴露,与区域BPA生产和饮食模式有关.
暴露与高等教育水平和18-44岁的年龄组有显著的相关性;瓶装水和外卖饮料的消费也增加了暴露.
没有人超过了基于RfD的BPA危险系数,但0.44%的人口面临潜在的非致癌风险.

结论:

双暴露在中国很普遍,具有特定的人口和区域差异.
饮食习惯和生活方式因素,如饮用瓶装水和外卖食品,有助于增加暴露.
虽然目前的BPA暴露对一般人群构成最小的非致癌风险,但有针对性的预防策略是合理的.

关键词:

双乙烯 A 是一种双乙烯.内部风险内部风险内部风险全国范围的国家规模.非致癌性风险非致癌性风险基基烯是一种基基.

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