在青少年接种异质或分量第二剂COVID-19疫苗后的反应性,免疫性和突破性感染 (Com-COV3):一个随机对照试验
Eimear Kelly1, Melanie Greenland1, Philip C S de Whalley1
1Oxford Vaccine Group, NIHR Oxford Biomedical Research Centre, Department of Paediatrics, University of Oxford, Oxford, UK.
The Journal of infection
|June 18, 2023
概括
青少年的异质和分量COVID-19疫苗接种计划是安全的和免疫的. 与标准方案相比,NVX-CoV2373疫苗显示对Omicron变异的增强保护.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 青少年健康 青少年健康
背景情况:
- 第一个关于青少年异质或分量第二剂COVID-19疫苗方案的研究.
- 研究了反应性,免疫性和安全性.
研究的目的:
- 在青少年中比较不同COVID-19疫苗增剂策略的安全性和免疫性.
- 为了评估异质 (BNT162b2主要,NVX-CoV2373增强) 和分数 (低剂量BNT162b2) 方案.
主要方法:
- 第二阶段,对148名健康青少年 (12-16岁) 进行随机对照试验.
- 参与者在第一个BNT162b2剂量后8周接受了30μg的BNT162b2 (BNT-30),10μg的BNT162b2 (BNT-10) 或NVX-CoV2373 (NVX) 的第二剂量.
- 主要结局:诱发全身反应;次要结局:免疫性和安全性.
主要成果:
- 反应是轻度至中度的,BNT-10接受者患病率较低. 没有严重的不良事件.
- 与BNT-30.30相比,NVX-CoV2373显示出类似或更高的抗体反应和更强的细胞免疫力对抗Omicron变异.
- NVX-CoV2373与89%的突破性感染风险降低有关; BNT-10显示风险增加.
结论:
- 异质和分量COVID-19疫苗计划是安全的,耐受性良好,在青少年中具有免疫性.
- 在mRNA主要和蛋白质子单元提升 (NVX-CoV2373) 可能提供更广泛的保护对SARS-CoV-2变种.
- 分量剂量 (BNT-10) 在预防突破性感染方面效率较低.
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