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在男性乳腺癌中表现出1型三鼻综合征 (TRPS1) 表现

Timothy Law¹, Matthew J Piotrowski², Jing Ning³

¹Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

Human pathology

|June 18, 2023

概括

TRPS1是一种高度敏感和特定的标记物,用于识别男性乳腺癌. 这种标志物在各种亚型中有效,可以区分原发性瘤和转移,有助于准确诊断.

科学领域:

在瘤学瘤学.
病理学病理学病理学
生物标志物研究生物标志物研究

背景情况:

由于缺乏特定标志物,对男性乳腺癌的准确诊断具有挑战性.
雌激素受体 (ER),GATA3和雄激素受体 (AR) 对男性乳腺癌的特异性和敏感性有局限性.
TRPS1是已知的女性乳腺癌特异性标记物,促使其在男性病例中进行评估.

研究的目的:

评估TRPS1作为男性乳腺癌的特定和敏感标记物的诊断实用性.
为了将TRPS1表达在原发性男性乳腺癌中的表达与其他常见的免疫组织化学标志物进行比较.
评估TRPS1在区分男性原发性乳腺癌与男性乳腺组织中转移性癌症中的有效性.

主要方法:

追溯分析72例初级侵入性男性乳腺癌病例.
对TRPS1,GATA3,ER,孕激素受体 (PR),HER2和AR进行免疫组合化学染色.
对29例转移到男性乳腺组织的转移性癌症的分析,用于TRPS1表达.

主要成果:

在ER/PR阳性 (97%) 和HER2阳性 (100%) 的男性乳腺癌中,TRPS1呈高阳性.
一个三阴性病例表现出高TRPS1阳性和GATA3阴性.
在93%的转移性癌症中,TRPS1是负的,只有在唾液腺原发性癌症中,中等阳性.

结论:

TRPS1是一种敏感和特定的标记物,用于识别各个亚型的男性原发性乳腺癌.
在乳腺转移性癌症中,TRPS1的表达在很大程度上不存在,这有助于差异诊断.
TRPS1为改善男性乳腺癌的诊断准确性提供了一个有价值的工具.

关键词:

雄激素受体 (AR) 是一种在 GATA3 和 GATA3 之间.男性的乳腺癌是男性的乳腺癌.转移到男性乳腺组织的转移性癌瘤.三鼻带综合征1型 (TRPS1) 是一种三重阴性乳腺癌 (TNBC) 是一种

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