了解通过胃肠道中神经免疫相互作用的食物过敏
1School of Biomedical Sciences & Pharmacy, College of Health, Medicine and Wellbeing, University of Newcastle, NSW, Australia; National Health and Medical Research Council Centre of Research Excellence in Digestive Health, University of Newcastle, Newcastle, NSW, Australia; Immune Health Research Program, Hunter Medical Research Institute, New Lambton Heights, NSW, Australia.
概括
新兴研究强调了免疫细胞和肠道神经系统神经元之间的通信在食物过敏中的关键作用. 针对这些神经免疫相互作用,为食物过敏治疗提供了有前途的新治疗策略.
科学领域:
- 免疫学 免疫学 免疫学
- 神经科学是一个神经科学.
- 胃肠病学 胃肠病学
背景情况:
- 食物过敏在全球范围内日益增加,涉及对食物蛋白质的不良免疫反应.
- 2型免疫反应是过敏敏感化的关键,但神经免疫交叉通话正在调查中.
- 肠道神经系统 (ENS) 的神经元和免疫细胞,如埃索诺菲尔和巨细胞,在肠道中密切相互作用.
研究的目的:
- 审查肠道神经免疫相互作用在食物过敏病理生理学中的作用.
- 探索免疫细胞和ENS神经元之间的双向通信如何影响过敏反应.
- 讨论未来针对食物过敏的神经免疫通路的治疗策略.
主要方法:
- 这是一篇综述性文章,综合了有关食物过敏和神经免疫学的现有研究.
- 它评估了关于免疫细胞和肠道神经元之间的双向通信的文献.
- 该审查考虑了神经调节对2型免疫反应的影响.
主要成果:
- 神经免疫相互作用对于感知危险信号和响应肠道炎症至关重要.
- 免疫细胞和ENS神经元通过神经,发射器和细胞因子的受体双向通信.
- 免疫细胞的神经调节,如巨细胞和埃索诺菲尔细胞,放大了2型过敏免疫反应.
结论:
- 肠道神经免疫相互作用是食物过敏免疫反应的组成部分.
- 针对这些神经免疫通路是未来食物过敏治疗的有希望的途径.
- 对神经免疫信号的进一步研究对于开发有效的治疗方法至关重要.
相关概念视频
01:37Neural Regulation
39.6K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.6K
01:05Physiology of Enteric Nervous System and Gut Health
333
The gastrointestinal tract, responsible for the digestion and absorption of nutrients, is safeguarded by the intestinal barrier, which consists of secretory, physical, and immune components. At the forefront is the secretory barrier, composed of essential elements such as mucus, gut microbiota, and defense proteins. They collaborate to break down food particles, facilitate nutrient absorption, and maintain optimal gut health. These secretory components ensure the smooth functioning of the...
333
01:27Allergic Drug Reactions
898
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
898
02:06Allergic Reactions
27.9K
Overview
27.9K
01:11Enteric Nervous System: Regulation of GI Motor Activity
493
The Enteric Nervous System (ENS) plays a pivotal role in regulating gastrointestinal or GI motor activity. This complex network of nerves, deeply embedded within the gut wall, responds to changes in the gut environment and receives input from both the autonomic nervous system and the central nervous system. By doing so, the ENS operates various programs tailored to the body's nutritional status and needs.
During periods of fasting, the ENS initiates the migrating myoelectric complex, a...
During periods of fasting, the ENS initiates the migrating myoelectric complex, a...
493
01:17Irritable Bowel Syndrome I: Introduction
326
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
326