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与癌症相关的纤维细胞:头部和部瘤的调解者微环境重塑

Martina Raudenska¹, Jan Balvan², Klara Hanelova²

¹Department of Physiology, Faculty of Medicine, Masaryk University / Kamenice 5, CZ-625 00 Brno, Czech Republic; Department of Pathological Physiology, Faculty of Medicine, Masaryk University / Kamenice 5, CZ-625 00 Brno, Czech Republic.

Biochimica et biophysica acta. Reviews on cancer

|June 18, 2023

概括

与癌症相关的纤维细胞 (CAFs) 通过改变瘤微环境 (TME) 来驱动头癌的进展. 准CAF及其信号通路为头部和部状细胞癌 (HNSCC) 提供了有希望的治疗策略.

科学领域:

在瘤学瘤学.
癌症生物学癌症生物学
瘤微环境研究研究

背景情况:

与癌症相关的纤维细胞 (CAFs) 显著影响头部和部状细胞癌 (HNSCC) 的发生.
在瘤微环境 (TME) 中,CAFs有助于瘤宽容的细胞外基质,血管生成和免疫/代谢重编程.
CAF的异质性和可塑性导致对致癌的情境依赖性影响,影响转移和治疗耐药性.

研究的目的:

审查CAF在HNSCC的TME中的多方面的作用.
探索针对CAF及其相关信号通路用于HNSCC治疗的潜力.
讨论针对CAF治疗HNSCC的临床相关药物的重新用途.

主要方法:

文献综述,重点关注CAF在HNSCC中的作用.
对CAF衍生信号和癌细胞中信号通路的分析.
对针对CAF的临床相关药物的评估.

主要成果:

CAFs是HNSCC进展的关键参与者,影响矩阵结构,血管生成和免疫/代谢景观.
CAF的异质性有助于它们在致癌和治疗耐药性方面的多样性作用.
特定的CAF特性为HNSCC治疗提供了众多可向的分子.

结论:

CAFs是HNSCC TME的关键组成部分,推动瘤进展和治疗耐药性.
准CAF及其信号通路代表了HNSCC一个有前途的治疗途径.
重新利用针对CAF的现有药物,有可能为新的HNSCC治疗策略提供潜力.

关键词:

癌症治疗治疗癌症治疗与癌症相关的纤维细胞.头癌是头部和部的癌症.对治疗的抗性.瘤微环境是一个微环境.

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