在复发性/转移性头部和部状细胞癌中,金的耐药性和敏感性
Yuto Horichi1, Hidetoshi Matsui1, Yuta Yamamura1
1Department of Head and Neck Surgery, Hyogo Cancer Center, 13-70 Kitaohji, Akashi, Hyogo 673-8558, Japan.
Auris, nasus, larynx
|June 18, 2023
概括
对于复发性/转移性头角状细胞癌,不到6个月的无间隔 (PFI) 表明抗性. 基于的化学疗法对患有6个月或更长时间PFI的患者来说是一个有效的选择.
科学领域:
- 在瘤学瘤学.
- 医学瘤学 医学瘤学
- 头部和部癌症研究研究
背景情况:
- 基于的化疗 (PBCT) 是对复发性/转移性头支状细胞癌 (R/MHNSCC) 的标准治疗方法.
- 在R/MHNSCC中基于无区间 (PFI) 的PBCT重试的有效性尚未得到充分证实.
- 了解基于PFI的敏感性对于优化R/MHNSCC的治疗策略至关重要.
研究的目的:
- 根据R/MHNSCC患者的PFI评估敏度的差异.
- 确定在R/MHNSCC中成功使用PBCT重新挑战的最佳PFI值.
主要方法:
- 在2001年至2020年期间,80名R/MHNSCC患者接受PBCT治疗的回顾性分析.
- 在重新挑战组 (之前的PBCT) 和对照组 (没有之前的PBCT) 之间的治疗疗效的比较.
- 根据PFI重新挑战组的分层 (<6个月,6-11个月,≥12个月).
主要成果:
- 与对照组相比,患有PFI <6个月的患者的整体存活率显著较短,疾病控制率较低.
- 在对照组和患有PFI 6-11个月或PFI ≥12个月的患者之间没有观察到结果的显著差异.
- 重新挑战组 (55名患者) 和对照组 (25名患者) 根据PFI显示出不同的生存模式.
结论:
- 低于6个月的PFI表明R/MHNSCC的抗性,导致PBCT再试验后的预后较差.
- 超过6个月的PFI可能表明白金敏感性,使PBCT重新挑战成为潜在的有效治疗选择.
- 在确定R/MHNSCC白金再挑战疗法的疗效方面,PFI是关键因素.
更多相关视频
07:29Intramucosal Inoculation of Squamous Cell Carcinoma Cells in Mice for Tumor Immune Profiling and Treatment Response Assessment
Published on: April 22, 2019
11.6K
11:28Isolation and Characterization of a Head and Neck Squamous Cell Carcinoma Subpopulation Having Stem Cell Characteristics
Published on: May 11, 2016
8.6K
相关概念视频
02:56Treatment Resistant Cancers
3.4K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.4K
02:57Targeted Cancer Therapies
7.7K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.7K