质可用性和乳病患病率之间的关系:一个地理流行病学系统性审查
Claire L Jansson-Knodell1, Melis G Celdir2, Isabel A Hujoel3
1Division of Gastroenterology, Hepatology, and Nutrition, Digestive Disease and Surgery Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Journal of gastroenterology and hepatology
|June 18, 2023
概括
含质的谷物可用性显示出与乳病患病率的混合关联. 在这项全球性研究中,较高的小麦摄入量与风险增加相关,而大麦和麦显示出保护作用.
科学领域:
- 流行病学 流行病学
- 胃肠病学 胃肠病学
- 遗传学 遗传学 是一个
背景情况:
- 乳病是一种免疫介导的肠病,在基因易受影响的个体中由质引发.
- 含有质的谷物对乳病患病率的全球影响尚不清楚.
- 了解这些关联对于公共卫生战略至关重要.
研究的目的:
- 调查基于国家的质可用性和乳病患病率之间的关联.
- 分析小麦,大麦和玉米消费对乳病发病率的影响.
- 探索人类白细胞抗原 (HLA) 频率和经济因素的作用.
主要方法:
- 2021年5月为止的MEDLINE,Embase,Cochrane和Scopus数据库的系统文献审查.
- 包括基于人群的研究,包括血清查和确认测试.
- 分析了联合国关于谷蛋白谷物和HLA频率的粮食平衡数据.
主要成果:
- 总共分析了来自41个国家的120项研究,涉及427,146名受试者.
- 增加的小麦供应显示出与乳病患病率有轻微的积极关联 (RR 1.002).
- 麦子 (RR 0.973) 和麦 (RR 0.989) 的可用性显示出保护性关联,除了更高的GDP和特定的HLA类型.
结论:
- 含有质的谷物可用性与乳病患病率存在复杂的关联.
- 消费小麦可能会增加风险,而大麦和麦似乎有保护作用.
- 需要进一步的研究来阐明饮食,遗传学和腹腔疾病之间的复杂关系.
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