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Updated: Jul 26, 2025

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基于结构的致病性关系标识符,用于预测单个误解变异的影响,并发现高阶癌症易感性突变群

Boshen Wang1, Xue Lei1, Wei Tian1

  • 1Center for Bioinformatics and Quantitative Biology, Richard and Loan Hill, Department of Biomedical Engineering, University of Illinois at Chicago, W103 Suite, 820 S Wood St, 60612 IL, USA.

Briefings in bioinformatics
|June 18, 2023
PubMed
概括

我们介绍了基于结构的致病性关系标识符 (SPRI),这是一个计算工具,可以准确预测突变对蛋白质结构和功能的影响. SPRI识别致病突变并发现新的致病突变集群.

关键词:
一个阿尔法形状的字母.癌症驱动突变是癌症的驱动突变.误解突变是一种错误的突变.突变集群是一个突变集群.病理影响 病理影响蛋白质结构 蛋白质结构

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