燃烧口腔综合征是否与压力有关? 一个元分析
André Luís Porporatti1, Ângela Graciela Deliga Schroder2, Ashley Lebel3
1Laboratoire de Neurobiologie Oro-Faciale (EA 7543), Université Paris Cité, France and GHPS Assistance Publique Hôpitaux de Paris, Paris, France.
Journal of oral rehabilitation
|June 18, 2023
概括
这一元分析揭示了口腔炎综合征 (BMS) 与增加的压力之间存在显著的关联. 与健康人相比,BMS患者的压力标志物和特定生物标志物的水平较高.
科学领域:
- 口腔医学是指口腔医学.
- 精神病体医学是一种精神病体医学.
- 生物标志物研究 生物标志物研究
背景情况:
- 燃烧口腔综合征 (BMS) 越来越多地被认为与心理社会和精神疾病有关.
- 压力被认为是导致BMS发展和恶化的重要危险因素.
研究的目的:
- 为了调查口腔炎综合征 (BMS) 和压力之间的联系.
- 为了比较BMS患者与健康对照者的压力水平和相关生物标志物.
主要方法:
- 进行了全面的元分析,搜索了五个主要数据库和灰色文献.
- 包括30项研究分析了各种问卷 (例如,DASS-21) 和生物标志物 (例如,皮质醇,IgA,α-amylase,interleukins).
主要成果:
- 基于问卷的研究始终显示,与对照人群相比,BMS患者的压力增加.
- 与健康对照组相比,BMS患者的皮质醇,α-氨基酶,IgA和IL-8水平显著更高.
- 没有发现opiorphin或其他几个介质蛋白 (IL-1β,IL-2,IL-4,IL-6,IL-10,TNF-α) 的显著差异.
结论:
- 证据支持增加的压力因素和BMS之间的联系.
- 皮质醇,α-氨基酶,IgA和IL-8的水平升高与口腔炎综合征有关.
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