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在下骨折和手术部位感染时使用手术前预防性抗生素
Abdelaziz Atwez1, Kayla Antosz2, Lindsey Cooper2
1From the Division of Plastic Surgery, University of South Carolina School of Medicine/Prisma Health.
Annals of plastic surgery
|June 19, 2023
概括
扩展的手术前抗生素不会降低手术部位感染 (SSI) 率,以修复下骨折. 一项研究发现,在接受多次手术前抗生素剂量和接受一次术后剂量或没有服用的患者之间,SSI率没有显著差异.
科学领域:
- 口腔和牙面部外科手术
- 预防传染病 预防传染病
- 手术部位感染 (SSI) 研究研究
背景情况:
- 骨折在面部骨折中表现出最高的术后部位感染率.
- 手术后的抗生素在减少手术部位感染 (SSIs) 方面没有被证明的好处,无论持续时间如何.
- 关于预防性手术前抗生素减少SSI的疗效,存在相互矛盾的数据.
研究的目的:
- 在接受下骨折修复的患者中比较SSI率.
- 为了评估手术前预防性抗生素对手术前或没有抗生素对SSI率的影响.
主要方法:
- 对接受下骨折修复 (2014-2019) 的成年患者进行了回顾性队列审查.
- 两个群体之间的SSI率的比较:接受1剂以上手术前抗生素的人和接受0-1剂周围抗生素的人.
- 主要结局:手术部位感染率 (SSI).
主要成果:
- 183名患者接受了1剂以上的术前抗生素;35名患者接受了0-1剂的术后抗生素.
- 在手术前抗生素组的SSI率为29.3%.
- 术后/没有抗生素组的SSI率为25.0%;没有发现显著差异.
结论:
- 扩展的手术前预防性抗生素治疗方案在下骨折修复后不会减少SSI.
- 目前的证据不支持在下骨折修复中使用多次手术前抗生素剂量,超过单次手术前剂量.
- 进一步的研究可能会澄清在这些程序中预防SSI的最佳抗生素策略.
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