衰老和肥胖对食道粘膜完整性的影响,用基线阻抗测量
Theodoros Voulgaris1, Shintaro Hoshino1, Daniel Sifrim1
1Barts and The London School of Medicine and Dentistry, Upper GI Physiology Unit Royal London Hospital, Wingate Institute of Neurogastroenterology, Blizard Institute, Queen Mary University of London, London, UK.
Neurogastroenterology and motility
|June 19, 2023
概括
低平均夜间基线阻抗 (MNBI) 值对于诊断胃食道逆流病 (GERD) 是至关重要的. 这项研究发现,年龄和BMI独立地影响MNBI,这表明在现实环境中,GERD的诊断截止线较低.
科学领域:
- 胃肠病学 胃肠病学
- 诊断医学 诊断医学 诊断医学
- 食道生理学 食道生理学
背景情况:
- 低平均夜间基线阻抗 (MNBI) 是诊断胃食道逆流病 (GERD) 的关键指标.
- 新出现的证据表明,患者的年龄和体重指数 (BMI) 可能会影响MNBI值.
- 人口统计因素可能会影响MNBI的诊断准确性.
研究的目的:
- 为了评估GERD诊断中MNBI的诊断切线.
- 评估衰老和BMI对MNBI值的影响.
- 在临床实践中完善MNBI解释.
主要方法:
- 一组311名患有典型的GERD症状的患者接受了高分辨率计量 (HRM) 和使用质子抑制剂 (PPI) 的pH阻抗研究.
- 在3,5和17厘米以上的下缩管 (LES) 上测量了MNBI.
- 如果酸暴露时间 (AET) 超过6%,则GERD诊断得到确认.
主要成果:
- MNBI与年龄,BMI,AET,LES-CD分离,总逆流事件和LES低血压相关.
- 多变量分析显示,3和5厘米的MNBI与年龄,BMI和AET独立相关.
- 与未确定的GERD或没有GERD患者相比,确定的GERD患者在3厘米处的MNBI较低.
结论:
- 年龄和BMI独立地影响GERD评估的患者的食道下部MNBI值.
- MNBI是GERD诊断的宝贵工具,但在临床实践中可能需要比以前建议的更低的切断值.
- 在GERD诊断中,MNBI在3厘米的最佳切线被确定为1281欧姆.
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