基于NLP和深度学习的药物不良反应的命名实体识别研究
Jianxiang Wei1, Tianling Hu2, Jimin Dai3
1School of Management, Nanjing University of Posts and Telecommunications, Nanjing, China.
Frontiers in pharmacology
|June 19, 2023
概括
这项研究引入了一种先进的ALBERT-BiLSTM-CRF模型,用于从在线文本中识别药物不良反应 (ADR). 新方法显著改善了药物名称,成分和ADR事件的识别,增强了公共卫生信息.
科学领域:
- 自然语言处理 (NLP) 是一种自然语言处理.
- 生物信息学是一种生物信息学.
- 公共卫生信息学 公共卫生信息学
背景情况:
- 药物不良反应 (ADR) 是一个重要的公共卫生问题,越来越多的报道在线.
- 目前挖掘和利用在线ADR信息的方法是不够的.
- 命名实体识别 (NER) 对于从文本中提取有意义的信息至关重要.
研究的目的:
- 开发一种更有效的方法来识别在线来源的ADR事件数据中的实体.
- 改善与药物不良反应相关的有价值的健康知识的提取.
- 为了提高名称实体识别 (NER) 对ADR相关信息的准确性.
主要方法:
- 为ADR命名实体识别 (NER) 提出了一个ALBERT-BiLSTM-CRF模型.
- 从"中国医疗信息查询平台" (https://www.dayi.org.cn) 收集的ADR文本数据.
- 用于三个实体类型的BIO标记:药物名称 (DRN),药物成分 (COM) 和药物不良反应 (ADR).
主要成果:
- 阿尔伯特-比尔斯TM-CRF模型获得了91.19%的F1得分.
- 这代表了比BiLSTM-CRF和BERT-BiLSTM-CRF模型的1.5%和1.37%的改进.
- 在识别药物名称,成分和ADR实体方面显著改进.
结论:
- 拟议的ALBERT-BiLSTM-CRF方法对在线ADR信息中的NER有效.
- 为提取与毒品有关的实体关系和构建知识图提供了基础.
- 促进实用的健康应用,如智能诊断,风险推理和自动化问题答案.
相关概念视频
Pharmacovigilance
914
Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
914
Drug Nomenclature
1.8K
During the development of a new pharmaceutical, the manufacturer initially assigns a code name to the drug. Once approved, the drug receives a United States Adopted Name (USAN)—a generic, nonproprietary designation. Upon being listed in the United States Pharmacopeia, this nonproprietary name becomes the drug's official name. Additionally, the manufacturer assigns a proprietary name or trademark, which serves as the brand name under which the drug is marketed. It is worth noting that...
1.8K
Allergic Drug Reactions
898
Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
898
Drug-Receptor Interaction: Agonist
2.6K
Agonists are drugs that interact with specific receptors in the body to produce a biological response. When an agonist binds to a receptor, it activates or enhances the receptor's function, leading to physiological effects. The interaction between agonist drugs and receptors is crucial for their therapeutic action in various medical treatments.
Agonists can bind to receptors in different ways. Some agonists bind directly to the receptor's active site, mimicking the endogenous...
Agonists can bind to receptors in different ways. Some agonists bind directly to the receptor's active site, mimicking the endogenous...
2.6K
Drug-Receptor Interaction: Antagonist
3.1K
An antagonist is a drug that binds strongly to a receptor without activating it. An antagonist prevents other molecules, such as neurotransmitters or hormones, from binding to the receptor and triggering a cellular response. Such interaction effectively hinders the normal physiological processes mediated by the receptor, resulting in various pharmacological effects depending on the specific receptor targeted.
Antagonists can be classified as competitive or noncompetitive based on their...
Antagonists can be classified as competitive or noncompetitive based on their...
3.1K
Drug-Receptor Interactions
5.4K
Drug-receptor interaction describes the binding of receptors by drugs, but not all drug-receptor interactions result in activation and tissue response. For instance, the binding of agonists activates the receptor to generate a cellular reaction, while antagonists bind to receptors without causing their activation.
Several parameters, such as the drug's affinity for its receptor and its efficacy, which is its ability to activate the receptor, determine the drug's effect on the tissue....
Several parameters, such as the drug's affinity for its receptor and its efficacy, which is its ability to activate the receptor, determine the drug's effect on the tissue....
5.4K


