埃塞俄比亚的抗疟疾工厂及其在抗药性疟疾方面的活动
Yimeslal Atnafu Sema1, Teshale Areda Waktola1
1School of Biological Sciences and Biotechnolog, Haramaya University, 138 Dire Dawa, Haramaya, Ethiopia.
FEMS microbes
|June 19, 2023
概括
埃塞俄比亚的耐药疟疾是一个主要问题. 传统的药用植物提供了潜在的植物化学化合物,如化物和黄类化合物,以对抗耐药的Plasmodium物种.
科学领域:
- 民族植物学 民族植物学
- 疟疾学 疟疾学
- 药用化学 医学化学
背景情况:
- 疟疾在埃塞俄比亚造成严重的发病率和死亡率,影响门诊服务.
- 埃塞俄比亚的目标是到2030年在全国范围内控制疟疾,包括分国家消除战略.
- 耐药疟疾寄生虫,特别是杆菌 (Plasmodium falciparum),对控制工作构成重大威胁.
研究的目的:
- 审查传统埃塞俄比亚药用植物的植物化学成分和多样性.
- 评估植物提取物对抗耐药性等杆菌物种的疗效.
- 为了识别具有抗疟疾活性的关键植物化学化合物.
主要方法:
- 关于82项关于传统埃塞俄比亚抗疟疾植物的研究的文献综述.
- 识别用于治疗疟疾的常用药用植物物种.
- 对报告中的植物化学成分及其生物活性进行分析.
主要成果:
- 在传统的埃塞俄比亚疟疾治疗中使用了200多种植物.
- 经常使用的是Allium sativum,Croton macrostachyus和Carica 番茄.
- 类化合物,黄类化合物,类化合物,类化合物和葡萄糖类化合物是关键的植物化学物质,据报道对抗耐药疟疾具有活性.
结论:
- 埃塞俄比亚的传统药用植物是抗疟疾药物发现的宝贵资源.
- 这些植物中的植物化学物质在对抗耐药疟疾菌株方面表现有前途.
- 对特定植物化合物的进一步研究可能会导致新的疟疾治疗策略.
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