在住院治疗SARS-CoV-2期间检测肺炎球菌
Anne Stahlfeld1, Laura R Glick2, Isabel M Ott1
1Department of Epidemiology of Microbial Diseases, Yale School of Public Health, LEPH823, 60 College St, New Haven, CT 06510, United States.
FEMS microbes
|June 19, 2023
概括
在11%的住院COVID-19患者中检测到肺炎球菌共感染,严重病例的发病率更高. 这表明肺炎球菌下呼吸道感染可能会加剧COVID-19的严重程度.
科学领域:
- 传染性疾病 传染性疾病
- 肺部病理学 肺部病理学
- 微生物学 微生物学
背景情况:
- 病毒性呼吸道感染增加了严重肺炎球菌感染的风险.
- 肺炎球菌共感染与病毒性呼吸道感染的更糟糕结果有关.
- 有限的数据存在于Streptococcus pneumoniae和SARS-CoV-2共感染及其对COVID-19严重性的影响.
研究的目的:
- 调查在早期大流行期间住院COVID-19患者中检测肺炎球菌的频率.
- 确定肺炎球菌联合感染和COVID-19严重程度之间的关联.
主要方法:
- 该研究包括148名成人COVID-19住院患者,这些患者住院于耶鲁-纽黑文医院 (2020年3月至8月).
- 通过唾液RT-qPCR检测肺炎球菌,以检测下呼吸道感染的载体和尿液抗原检测 (UAD) 试验.
- 患者进行了SARS-CoV-2阳性和疾病严重程度的测试.
主要成果:
- 在3.1%的患者中检测到肺炎球菌携带者.
- 在11.0%的患者中通过UAD检测到肺炎球菌,在严重的COVID-19中更常见 (OR:2.20).
- 没有UAD阳性患者死亡,但数量很少.
结论:
- 肺炎球菌下呼吸道感染 (LRTI) 发生在住院的COVID-19患者中.
- 肺炎球菌LRTI在患有严重COVID-19结局的患者中更为频繁.
- 需要进一步研究肺炎球菌和SARS-CoV-2在COVID-19严重程度上的相互作用.
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