肠道脂肪酸结合蛋白与慢性心力衰竭中的心脏功能和肠道失调有关
Andraž Nendl1,2, Sajan C Raju3, Kaspar Broch4
1Center for Clinical Heart Research, Department of Cardiology, Oslo University Hospital Ullevål, Oslo, Norway.
Frontiers in cardiovascular medicine
|June 19, 2023
概括
在心力衰竭 (HF) 患者中,增加的肠脂肪酸结合蛋白 (I-FABP) 表明肠道屏障功能障碍,并与较低的肠道微生物多样性有关. 这表明I-FABP可能作为肠道参与HF严重程度的标志物.
科学领域:
- 胃肠病学 胃肠病学
- 心脏病学 心脏病学
- 微生物组研究 微生物组研究
背景情况:
- 慢性心力衰竭 (HF) 与肠道细菌多样性减少和代谢物合成受损有关.
- 在HF中,肠道功能失调可能导致肠道透性增加,全身炎症和免疫激活.
- 这项研究探讨了HF患者的肠道微生物群,肠道屏障完整性,炎症和心脏功能之间的联系.
研究的目的:
- 调查肠道微生物群多样性和慢性心力衰竭 (HF) 中的肠道屏障功能障碍标志物之间的关系.
- 评估肠道屏障功能障碍,炎症标志物和HF严重程度之间的关联.
- 为了确定受HF严重程度和肠道屏障完整性影响的特定细菌种群.
主要方法:
- 纳入了151名稳定的HF患者,其左心室喷射率 (LVEF) <40%.
- 用脂聚糖 (LPS),脂聚糖结合蛋白 (LBP),肠脂肪酸结合蛋白 (I-FABP) 和可溶性分化集群14 (sCD14) 来评估肠道屏障功能障碍.
- 使用16S rRNA基因测序和香农多样性指数分析了肠道微生物群的多样性;HF严重程度以N-终端亲B型尿素 (NT-proBNP) 标记.
主要成果:
- 严重的HF患者 (NT-proBNP> 895 pg/ml) 呈现出升高的I-FABP和LBP水平.
- I-FABP是严重HF的显著预测因素 (AUC = 0.70) 和与NT-proBNP水平正相关.
- 增加的I-FABP水平与肠道微生物多样性 (香农指数) 的减少以及特定细菌属的枯竭有关,包括Ruminococcus gauvreauii群,Bifidobacterium,Clostridium sensu stricto和Parasutterella.
结论:
- 肠道脂肪酸结合蛋白 (I-FABP) 与HF严重程度和微生物多样性降低有关,表明肠道屏障功能障碍.
- 在HF患者中I-FABP水平升高可能反映肠道失调和肠道透性增加.
- 在心力衰竭的病理生理学中,I-FABP作为肠道参与的潜在生物标志物.
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