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冲动控制障碍的过程帕金森病的症状:深度大脑刺激与药物对比

Pilar Hernandez-Con¹, Iris Lin², Eugenia Mamikonyan³

¹Department of Pharmaceutical Outcomes and Policy University of Florida Gainesville Florida USA.

Movement disorders clinical practice

|June 19, 2023

概括

深度大脑刺激 (DBS) 在帕金森病 (PD) 患者的12个月内没有改变冲动控制障碍 (ICD) 症状,与仅用药物治疗相比. 对两个治疗组来说,监测ICD至关重要.

科学领域:

神经学神经学
神经外科神经外科
精神病学是一个精神病学.

背景情况:

深度大脑刺激 (DBS) 手术对帕金森病患者的冲动控制障碍 (ICD) 的影响尚不清楚.
ICDs是用于PD管理的多巴胺类疗法的潜在副作用.

研究的目的:

为了比较接受DBS的PD患者中ICD症状的变化,与仅接受药物治疗的对照组相比.
为了确定影响PD患者ICD症状进展的因素.

主要方法:

一项为期12个月的前性观察性研究,涉及54名PD患者 (26名DBS,28名仅服用药物).
参与者因年龄,性别,多巴胺激动剂使用和基线ICD存在而匹配.
冲动控制障碍的症状在多个时间点使用帕金森病评分尺度 (QUIP-RS) 冲动-强迫性障碍问卷进行了评估.

主要成果:

在12个月后,DBS和仅服用药物组之间的QUIP-RS得分相似 (6.6对6.0).
较高的基线QUIP-RS得分和时间变化的利沃多巴每日相当剂量 (LEDD) 预测了ICD症状的变化.
8名患者 (每组4名) 出现了新的ICD症状,但没有人符合完整的诊断标准.

结论:

在12个月后的PD患者中,DBS手术并没有导致ICD症状与仅用药治疗相比显著的差异.
在两组中都出现了新的ICD症状,突出显示了持续监测的必要性.
密切监测ICD症状对于所有PD患者至关重要,无论治疗方式 (手术或药物).

关键词:

LEDD LEDD LEDD LEDD LEDD LEDD LEDD LEDD LEDD LEDD LEDD LEDD LEDD LEDD LEDD LEDD LEDD LEDD LEDD LEDD LEDD LEDD LEDD LEDD LEDD LEDD LEDD LEDD LEDD LEDD LEDD LEDD LEDD LEDD LEDD 帕金森病的疾病.在新的一年里,ICDs.深度大脑刺激刺激大脑多巴胺作用药物药物

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