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两个用于确定尿离子相对超和度的软件程序的比较
Reshma M Anthony1, Stephen Davidson1, Jennifer M MacLeay1
1Hill's Pet Nutrition, Inc., Topeka, KS, United States.
Frontiers in veterinary science
|June 19, 2023
概括
一个新的程序准确计算物尿液相对超和 (RSS),有助于了解尿病风险. 这种工具有助于管理狗和猫的尿路结石形成.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 计算化学计算化学
- 生物化学 生物化学
背景情况:
- 相对超和 (RSS) 量化了尿液晶形成风险,对于管理尿病至关重要.
- 兽医中RSS的现有计算工具往往缺乏透明度或更新的系数.
- 早期RSS计算工具EQUIL2程序在其更新的版本中存在关于公式可访问性的限制.
研究的目的:
- 为了评估一个新的RSS计算程序与透明的系数与原来的EQUIL2程序对比.
- 为了验证新程序在计算犬类和猫类尿样的RSS值时的准确性.
- 建立一种可靠的方法,以使用最新的计算工具来评估物中的尿病风险.
主要方法:
- 由新程序和原始EQUIL2程序生成的RSS值的比较.
- 统计分析包括t测试,相关性分析 (r2) 和林的一致性相关系数.
- 布兰德-阿尔特曼分析对两项计划的输出进行了分析,使用了健康的狗和猫的尿样.
主要成果:
- 新计划的氨酸 (struvite) 和酸盐的RSS值与原计划的值高度相关.
- 虽然绝对RSS值因更新的系数和常数而有所不同,但趋势 (上升和下降) 相对一致.
- 该研究证实了新程序能够准确地反映与已建立的EQUIL2程序观察到的RSS趋势.
结论:
- 现代化的RSS程序提供了一种可靠和透明的方法,用于评估兽医学中的尿病风险.
- 这种经过验证的工具有助于更好地了解狗和猫的石头形成风险.
- 这项研究为利用最新的计算方法在伴侣动物尿病管理中奠定了基础.
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