肝硬化患者肝脏水胸病的危险因素:一项临床回顾性研究
Xue Bai1, Xiaoyan Liu2, Yanhui Shi1
1Cheeloo College of Medicine, Shandong University, Jinan, China.
Frontiers in medicine
|June 19, 2023
概括
肝硬化患者的肝液胸与较高的MELD得分和门静脉问题有关. 较低的高密度脂蛋白和前激素活性,以及较高的D-二聚体和免疫球蛋白G,也是危险因素.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 肺部病理学 肺部病理学
- 内部医学 内部医学
背景情况:
- 肝脏水胸,一种无法解释的多叶膜溢出,是末期肝硬化患者的关键并发症.
- 它显著影响患者的预后和死亡率.
研究的目的:
- 在肝硬化患者中确定与肝脏水胸病相关的危险因素.
- 为了更好地了解这种危及生命的并发症.
主要方法:
- 在2013-2021年期间住院的978名肝硬化患者的回顾性分析.
- 患者被分为观察 (肝脏水胸) 和对照组.
- 分析了流行病学,临床,实验室和放射学数据;ROC曲线评估了模型预测能力.
主要成果:
- 观察组显示上部胃肠道出血率较高,脊髓切除病史和末期肝病 (MELD) 模型得分较高.
- 与门静脉宽度 (PVW),前热血素活性 (PTA),D-二次体,免疫球蛋白G (IgG),高密度脂蛋白胆固醇 (HDL) 和MELD得分发现了重要的关联.
- 预测模型的AUC为0.805;门静脉血栓症在双边多溢液中更为普遍.
结论:
- 肝脏水胸与较低的HDL,PTA和较高的PVW,D-二聚体,IgG和MELD得分相关.
- 门静脉血栓症在双边肝脏水胸部比单边病例更常见.
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