未烤的绿色咖啡提取物装载的固体脂质纳米颗粒用于增强肠道透
Yomna A Moussa1, Mahmoud H Teaima2, Dalia Attia1
1Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, The British University in Egypt (BUE), 11837 El-Sherouk City, Cairo, Egypt.
ACS omega
|June 19, 2023
概括
绿色咖啡豆提取物 (GCBE) 的生物可用性通过使用固体脂质纳米颗粒 (SLN) 来提高. 这种纳米封装改善了胆酸的肠道吸收,这是GCBE的一个关键化合物.
科学领域:
- 制药科学 制药科学
- 纳米技术纳米技术
- 自然产品 化学 化学
背景情况:
- 绿色咖啡豆提取物 (GCBE) 提供健康益处,但其生物可用性较低.
- 低生物可用性限制了GCBE的治疗潜力和应用.
- 提高GCBE吸收对于其有效利用至关重要.
研究的目的:
- 开发和优化绿色咖啡豆提取物载固体脂质纳米粒子 (GCBE-SLNs).
- 改善GCBE的肠道吸收和生物可用性.
- 评估纳米封装GCBE在增强酸输送方面的潜力.
主要方法:
- 用GCBE装载的SLN是使用高切割均化来准备的.
- 使用Box-Behnken设计优化了配方参数 (脂质,表面活性剂,共同表面活性剂度).
- 分析了物理化学性质 (颗粒大小,PDI,z-潜力,捕获效率,药物释放).
- 一个ex vivo everted袋模型被用于评估肠道透.
主要成果:
- 优化的GCBE-SLNs的粒子大小为235.7nm,PDI为0.417, ζ电位为-15mV.
- 实现了高捕获效率 (58.3%) 和累积药物释放率 (75.75%).
- 在ex vivo模型中,纳米封装显著改善了GCBE的肠道透.
结论:
- 开发的GCBE-SLNs成功地提高了GCBE的生物可用性.
- 固体脂质纳米颗粒为改善天然化合物的口服输送提供了一个有希望的策略.
- 这种方法有可能促进来自GCBE的酸的肠道吸收.
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