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系统工程方法对慢性阻塞性肺病的建模和分析

Varghese Kurian¹, Navid Ghadipasha¹, Michelle Gee^1,2

¹Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, Delaware 19716, United States.

|June 19, 2023

概括

这项研究使用工程原理模拟心肺呼吸系统,以了解慢性阻塞性肺病 (COPD). 增加的呼吸道阻力被确定为影响COPD患者心肺呼吸系统的关键因素.

科学领域:

系统工程是系统工程.
心血管呼吸系统生理学
计算建模计算建模

背景情况:

慢性阻塞性肺病 (COPD) 是一种进展性肺病,其特点是空气流量受限.
了解COPD复杂的机制对于有效管理至关重要.
现有的模型可能无法完全捕捉整合心肺呼吸反应.

研究的目的:

开发一个系统工程框架来建模COPD.
代表心肺呼吸系统作为一个综合生物控制系统.
为了确定COPD临床表现的关键生理参数.

主要方法:

使用四个工程控制系统组件建模心肺呼吸系统:传感器,控制器,执行器和过程.
整合了人类解剖学和生理学,以创建机械数学模型.
对计算模型进行了系统分析和多变量分析.

主要成果:

确定了重现COPD表现的三个关键生理参数:呼吸道阻力,肺弹性和肺阻力.
这些参数的量化变化导致了COPD诊断系统反应.
发现气道阻力变化对心肺呼吸系统有显著影响.

结论:

开发的系统工程框架有效地模拟了COPD机制.
增加的呼吸道阻力是COPD心肺呼吸系统功能障碍的主要驱动因素.
肺循环在COPD患者中受到显著的压力,特别是在低氧条件下.

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