在多发性硬化症中,基底功能连接的功能障碍与主观和认知疲劳相关
Christelle Langley1,2, Naoki Masuda3,4, Simon Godwin3
1CRIC Bristol, Bristol Medical School, University of Bristol, Bristol, United Kingdom.
Frontiers in neuroscience
|June 19, 2023
概括
多发性硬化症 (MS) 中心疲劳与基底腺功能有关. 基底质内局部连接性下降有助于认知疲劳,而全球连接性增加可能是补偿性的.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 医疗成像医学成像
背景情况:
- 中枢疲劳是多发性硬化症 (MS) 的普遍和衰弱症状,显著影响生活质量和认知功能.
- 尽管MS疲劳背后的精确神经生物学机制具有重大影响,但人们对其了解甚少.
- 基底腺因应于疲劳,但它们在MS疲劳中的具体作用和参与尚不清楚.
研究的目的:
- 通过功能连接 (FC) 测量,研究基底在MS疲劳中的作用.
- 探索基底性结FC与MS患者疲劳的主观和客观测量之间的关系.
- 为了确定潜在的神经生理学生物标志物疲劳在MS.
主要方法:
- 功能性磁共振成像 (fMRI) 用于评估40名女性多发性硬化患者和40名年龄匹配的健康对照 (HC) 的基底腺功能连接.
- 使用疲劳严重度表 (FSS) 来测量主观疲劳和认知疲劳的警觉运动范式来测量疲劳.
- 记录了力度测量,以区分物理和中心疲劳.
主要成果:
- 在MS患者中,基底腺内的局部功能连接性下降与认知疲劳有关.
- 基底和皮质之间的全局功能连接的增加似乎充当了缓解疲劳的补偿机制.
- 该研究发现,在MS中,基底功能连接和主观和客观疲劳指标之间存在显著的关联.
结论:
- 这项研究提供了新的证据,将基底功能连接与多发性硬化症疲劳联系起来.
- 在疲劳任务期间,在基底腺体内的局部功能连接可以作为MS相关疲劳的神经生理生物标志物.
- 了解MS疲劳中的基底腺参与,为治疗干预提供了潜在的目标.
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