TRP道:神经退行性疾病中的作用和治疗目标
Mashoque Ahmad Rather1, Andleeb Khan2, Lianchun Wang1
1Department of Molecular Pharmacology & Physiology, Bryd Alzheimer's Research Institute, Morsani College of Medicine, University of South Florida, Tampa, United States.
Heliyon
|June 19, 2023
概括
暂时受体潜能 (TRP) 道调节生理过程,对大脑功能至关重要. TRP通道的失调有助于神经退行性疾病,提供潜在的治疗点.
科学领域:
- 神经科学是一个神经科学.
- 分子生物学分子生物学
- 生理学 生理学 生理学
背景情况:
- 短暂受体潜能 (TRP) 通道是离子通道的超级家族,可以透过单价和双价离子.
- TRP通道被分为六个子家族 (TRPC,TRPV,TRPM,TRPP,TRPML,TRPA),并通过多种细胞类型和组织表达.
- 这些通道对于调节许多生理过程至关重要,并对物理,化学和热刺激作出反应.
研究的目的:
- 审查TRP通道在中枢神经系统中的生理和病理作用.
- 探索TRP通道在神经退行性疾病中的参与.
- 确定针对神经退行性疾病的TRP通道的潜在治疗干预措施.
主要方法:
- 对TRP通道和神经退行性疾病研究的文献综述.
- 在神经元和非神经元细胞中分析TRP通道功能.
- 检查TRP通道参与平衡和细胞信号通路的研究.
主要成果:
- TRP通道在大脑组织中得到广泛表达,并在神经元外生,受体信号传递和激发性细胞死亡中发挥作用.
- 由于TRP通道功能障碍导致的平衡中乱与阿尔茨海默氏症,帕金森病,亨廷顿病和ALS等神经退行性疾病有关.
- TRP通道活性与这些神经疾病的病理生理学有关.
结论:
- TRP通道是神经元功能和平衡的关键调节者.
- TRP通道功能障碍是神经退行性疾病发展和进展的重要因素.
- 准TRP道为开发针对阿尔茨海默氏症,帕金森症和其他神经系统疾病的新疗法提供了一个有希望的途径.
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