纤维细胞激活蛋白在肉瘤中的表达.
Jacquelyn N Crane1, Danielle S Graham2, Christine E Mona3
1Department of Pediatrics, Division of Pediatric Hematology, Oncology, Stem Cell Transplantation & Regenerative Medicine, Stanford University School of Medicine, 1000 Welch Rd, Suite 300, Palo Alto, CA 94304, USA.
Sarcoma
|June 19, 2023
概括
纤维细胞激活蛋白α (FAP) 在大多数肉瘤样本中表达. 需要进一步的研究来探索FAP.
科学领域:
- 在瘤学瘤学.
- 癌症生物学 癌症生物学
- 生物标志物研究 生物标志物研究
背景情况:
- 纤维细胞激活蛋白α (FAP) 是癌症相关纤维细胞的关键标记物,在上皮癌中普遍存在.
- 它在瘤中的表达和作用,这是一个多样化的结缔组织瘤群,仍然在很大程度上没有特征.
研究的目的:
- 为了研究各种类型的肉瘤亚型中的FAP表达模式.
- 评估FAP作为沙尔科马的诊断,治疗和预后标记物的潜力.
主要方法:
- 免疫组织化学 (IHC) 用于评估63个肉瘤组织样本和30个相邻的正常组织中的FAP表达.
- 半定量和定性评分系统评估了树皮和瘤细胞中的FAP强度和密度.
- 来自公共数据库的RNA测序数据 (n=10,626) 对癌症类型中的FAP表达进行了比较,并分析了168名肉瘤患者与整体存活 (OS) 的关联.
主要成果:
- 大多数肉瘤样本在肌细胞 (77.7%) 和瘤细胞 (50.7%) 中都表现出显著的FAP表达.
- 特定类型的肉瘤,包括desmoid纤维素瘤和未分化形肉瘤,显示FAP分数中等至高.
- 与其他癌症类型相比,瘤在RNA测序分析中显示出高平均FAP表达.
- 在肉瘤患者的FAP表达水平和整体存活率之间没有发现显著的相关性.
结论:
- 瘤经常显示FAP表达在树皮和瘤两部分.
- 作为肉瘤研究中的潜在诊断和治疗目标,FAP需要进一步调查.
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