乳腺癌区域节点辐射使用体积调制弧线疗法:心声图功能结果
Anthony Yu1, Charlie White1, Zhigang Zhang1
1Memorial Sloan Kettering Cancer Center.
Research square
|June 19, 2023
概括
对于乳腺癌患者的区域节点辐射 (RNI) 的体积调制弧线疗法 (VMAT) 没有显示显著的早期心脏功能下降. 这种VMAT方法可能有助于在需要RNI的患者中减少心脏辐射暴露.
科学领域:
- 在瘤学瘤学.
- 辐射瘤学 辐射瘤学
- 心脏病学 心脏病学
背景情况:
- 区域节点辐射 (RNI) 改善了乳腺癌的结果,但可以增加心脏辐射剂量.
- 量度调制弧线疗法 (VMAT) 正在探索减轻高剂量心脏暴露,尽管它对心脏功能的影响需要进一步调查.
- 与较旧的技术相比,VMAT对RNI的心脏影响尚未完全理解.
研究的目的:
- 评估基于VMAT的RNI在乳腺癌患者的早期心脏影响.
- 为了评估心脏功能的回声心脏学参数在RNI的VMAT之后的变化.
- 为了将心脏功能的变化与心脏的辐射剂量相关联.
主要方法:
- 预期招募接受RNI辅助VMAT的符合条件的患者.
- 在RT前,RT后和RT后6个月进行心声图.
- 在RT前和之后的心声学参数 (LVEF,GLS) 的比较,以及与心脏辐射剂量的相关性.
主要成果:
- 在VMAT RNI. 6个月后,左心室喷射率 (LVEF) 或全球纵向应变 (GLS) 没有显著下降.
- 没有个体患者显示LVEF降低或GLS持续下降.
- 在LVEF或GLS的变化与心脏平均或最大剂量之间没有发现相关性.
结论:
- 对于左侧RNI的VMAT并没有导致显著的早期心脏功能障碍.
- 在接受RNI的患者中,VMAT可能是节省心脏的可行策略,即使同时进行化疗 (人环素,HER2向治疗).
- 需要进行更大规模的随访研究来证实这些发现.
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