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Updated: Jul 26, 2025

Evaluation of Planar-Cell-Polarity Phenotypes in Ciliopathy Mouse Mutant Cochlea
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纤毛病的自主和非细胞自主病因 相关的结构性出生缺陷

Richard Francis, Jovenal T San Agustin, Heather L Szabo Rogers

    bioRxiv : the preprint server for biology
    |June 19, 2023
    PubMed
    概括

    皮对于发育至关重要. 研究小鼠Ift140缺陷揭示了毛在预防结构性出生缺陷,特别是面和身体壁问题方面的特定时间要求,并突出了先天性心脏缺陷的复杂起源.

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    Nondisjunction is the failure of homologous chromosomes or sister chromatids to separate correctly and move to the opposite poles of the cells. This produces daughter cells with abnormal chromosome numbers.  Nondisjunction is common during anaphase I or anaphase II of meiosis.  Mutations in synaptonemal complex proteins that attach homologous chromosomes increase the chances of nondisjunction in anaphase I of meiosis I. In contrast, mutations in topoisomerases and condensins that hold...
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