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Updated: Jul 26, 2025

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对人类胰腺小岛的单细胞转录基因分析显示,在24小时内对葡萄糖暴露有反应的基因

Caleb M Grenko1, Lori L Bonnycastle1, Henry J Taylor1,2

  • 1Center for Precision Health Research, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.

bioRxiv : the preprint server for biology
|June 19, 2023
PubMed
概括

高葡萄糖影响人类胰腺小岛基因表达,揭示了与2型糖尿病 (T2D) 发展相关的关键途径. 这项研究通过详细的转录基因分析确定了363个影响T2D风险的候选基因.

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Glucose Homeostasis: Pancreatic Islets and Insulin Secretion01:27

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The pancreatic islets comprising only 1%-2% of the volume are highly vascularized and innervated mini-organs. They contain five endocrine cell types, including β cells that secrete insulin, which is synthesized as a single polypeptide chain, preproinsulin, processed to proinsulin, and finally to insulin and C-peptide. This process is complex and regulated, involving the Golgi complex, the endoplasmic reticulum, and the secretory granules of the β cell.
Insulin and C-peptide are...
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