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Updated: Jul 26, 2025

Substrate Generation for Endonucleases of CRISPR/Cas Systems
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Published on: September 8, 2012

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在Cas4/1双核酶活动中,可以在I-G型CRISPR-Cas系统中实现预空间器成熟和定向集成

Yukti Dhingra1, Dipali G Sashital1

  • 1Roy J. Carver Department of Biochemistry, Biophysics, & Molecular Biology, Iowa State University, Ames, IA, USA.

bioRxiv : the preprint server for biology
|June 19, 2023
PubMed
概括

在CRISPR-Cas系统中,Cas4/1融合蛋白用于高效的DNA适应. 这种双重功能酶处理DNA间隔器并确保正确的整合,增强宿主对外来DNA的免疫力.

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