对可卡因的惩罚抵抗与老鼠不灵活的习惯有关
Bradley O Jones1, Morgan S Paladino2, Adelis M Cruz2
1Institute for Neuroscience, Texas A&M University, College Station, TX, USA.
bioRxiv : the preprint server for biology
|June 19, 2023
概括
在成中,对惩罚的抵抗与不灵活的寻找毒品的习惯有关. 这些习惯即使在负面后果引发目标导向控制时也会持续存在,这表明成模型中的不适应行为.
科学领域:
- 神经科学是一个神经科学.
- 行为科学 行为科学
- 成研究 研究成研究
背景情况:
- 成包括持续使用药物,尽管有不良后果.
- 在一些自给可卡因的老鼠中观察到的对惩罚的抵抗力,突出显示了在面对负面后果时无法改变行为.
研究的目的:
- 调查可卡因寻找的惩罚抵抗是否源于对习惯行为缺乏目标导向的控制.
- 确定习惯性与目标导向可卡因寻求和对惩罚的抵抗之间的关系.
主要方法:
- 鼠被训练在可卡因自我管理的时间表.
- 惩罚测试涉及自行管理期间发放的脚震.
- 以目标为导向的控制被评估使用结果值 (可卡因腹感) 在惩罚之前和之后.
主要成果:
- 对惩罚的抵抗与习惯性寻找可卡因的持久性相关,特别是在受到惩罚后.
- 对惩罚的敏感性与对寻找可卡因的目标导向控制增加有关.
- 在食物自我管理模型中观察到类似的模式,将惩罚抵抗与惩罚后的习惯性反应联系起来.
结论:
- 在成模型中,对惩罚的抵抗与不灵活的习惯性行为有关,当面临负面后果时,这些习惯性行为无法过渡到目标导向控制.
- 这些发现表明,习惯的持久性在不适应性药物使用中发挥着关键作用,尽管受到惩罚.
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